• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of King Saud University >Hepato-renal toxicity of Myristica fragrans Houtt. (Myristicaceae) seed extracts in rats
【24h】

Hepato-renal toxicity of Myristica fragrans Houtt. (Myristicaceae) seed extracts in rats

机译：肌瘤的肝肾毒性 houtt。 （MyRisticaceae）大鼠种子提取物

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

ObjectivesMyristica fragransis used in many parts of the world as a common spice and herbal medicine for managing a wide variety of ailments. The rich nutritional factors in M. fragrans seeds show potential application in food biofortification; however, the long-term safety of using a high dose of the seeds needs to be validated. This study seeks to investigate how oral administration of high doses of methanol (ME) and n-hexane (NHE) extracts ofM. fragransseed for one or two weeks affects the histology and serum markers of kidney and liver of rats.MethodsAdult male Swiss mice (6–7?weeks, 20–30?g) were used for acute toxicity study by standard methods, while male Wistar rats (6–8?weeks, 100–120?g) were used for sub-acute toxicity test. The sixty rats were distributed into five groups of 12 rats each: Group 1 received normal saline, groups 2 and 3 were orally treated with 500 and 1000?mg/kg b.w/day ME while groups 4 and 5 were fed 500 and 1000?mg/kg b.w/day NHE, respectively for 14?days. Six rats from each group were sacrificed on days 8 and 15 after 24?h of fasting. Markers of kidney and liver status of test and control animals were compared using one-way analysis of variance.ResultsThe presence of terpenoids, flavonoids, alkaloids, phenols, steroids, and tannins were detected in both extracts, although at varying levels. There was no obvious sign of toxicity nor mortality in acute toxicity test after 24?h of administration of extracts up to 5000?mg/kg b.w. However, there were significant (p?
机译：Objectivesmyristica Fragransis在世界许多地方使用，作为管理各种疾病的常见香料和草药。 M.Fragrans种子的富营养因子显示出潜在的食品生物侵蚀应用;然而，需要验证使用高剂量种子的长期安全性。该研究旨在调查甲醇（ME）和正己烷（NHE）提取物的高剂量施用的口服施用。一零间或两周的植物对肾脏和肝脏的组织学和血清标志物。方法草后雄性瑞士小鼠（6-7？周，20-30μg）用于通过标准方法进行急性毒性研究，而男性Wistar大鼠（6-8？周，100-120？g）用于亚急性毒性试验。将六十只大鼠分为5组12只大鼠：第1组接受的生理盐水，组2和3次，用500和1000℃口服处理，而第4组和5组喂500和1000？mg / kg bw / day nhe，分别为14个月。在禁食24℃和15天和15天和15天中牺牲了来自每组的6只大鼠。使用单向分析比较肾脏和肝脏肝脏的标记和肝脏的试验和对照动物的状态进行比较。在两种提取物中检测到萜类化合物，类黄酮，生物碱，酚，类固醇，类固醇，类固醇和单宁。毒性没有明显的毒性迹象，急性毒性试验后24℃的毒性试验高达5000？Mg / kg B.W.然而，尿素，总胆红素和肌酐浓度，碱性磷酸酶，天冬氨酸和丙氨酸氨基转移酶的显着（p？<β0.5）升高，以及在大鼠喂养七十四天的大鼠乳酸脱氢酶活性相对于对照。此外，在1000℃下的正己烷提取物引发了与肝毒性一致的一些组织学变化。结论摘要在一些必需的植物化学物质中富含富含植物化学物质，这项研究表明，长期施用高剂量提取物引发肝肾毒性。因此，气馁消耗大量的种子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号