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首页> 外文期刊>Journal of surgery and medicine. >Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study
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Effects of treatment with hydroxychloroquine and azithromycin on the index of cardiac electrophysiological balance in patients with COVID-19: A retrospective cohort study

机译：羟氯喹和二十霉素治疗对Covid-19患者心脏电生理平衡指标的影响：回顾性队列研究

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Background/Aim: The common cardiac toxicities of hydroxychloroquine (HCQ) and azithromycin (AZ) are not well defined in COVID-19 patients. Index of cardiac electrophysiological balance (iCEB) is used as a novel risk marker for drug-induced arrhythmias. The purpose of this study was to evaluate ventricular repolarization using iCEB and other conventional ECG parameters such as the end of electrocardiographic T wave (Tp-e) interval, Tp-e/QT ratio, and Tp-e/ heart rate-corrected QT (QTc) ratio in COVID-19 patients treated with HCQ and AZ. Methods: This retrospective study enrolled 164 patients diagnosed with COVID-19 pneumonia in the Emergency Department (ED) and then transferred to the ward or the intensive care unit in April 2020. Results: A total of 164 patients with a mean age of 47 (18) years (range: 18-97 years) included 83 (50.6%) females. There were 38 and 126 patients in Groups HTQ and HTQ+AZ, respectively. On the 5th day of hospitalization, all patients’ heart rates were significantly lower (P0.001), while QTc, QT max (V5-V6), QTmin, Tp-e (V5-V6), and iCEB values were significantly higher (P=0.01 and P0.001 for the rest, respectively) compared to the basal values measured in the ED (P0.001). iCEB values of the HTZ+AZ group were significantly higher than those of the HTQ group (P=0.03). iCEBc strongly positively correlated with Tp-e/QT (V5), and strongly negatively correlated with Tp-e (V5). Conclusion: The iCEB values were increased after HTQ and AZ treatment among COVID-19 patients, and strongly correlated with Tp-e and Tp-e/QT. iCEB is a simple, non-invasive method that can be a useful marker to evaluate ventricular repolarization in COVID-19 patients.
机译：背景/目的：在Covid-19患者中，羟基氯喹（HCQ）和二十霉素（AZ）的常见心脏毒性并不明确定义。心脏电生理平衡指数（ICEB）用作药物诱导心律失常的新风险标志物。本研究的目的是使用ICEB和其他常规ECG参数评估心室复极化，例如心电图T波（TP-E）间隔的结束，TP-E / QT比和TP-E /心率校正QT（ Covid-19患者的QTC）比率HCQ和AZ治疗。方法：该回顾性研究注册了164名患者在急诊部（ED）中诊断患有Covid-19肺炎的患者，然后于2020年4月转移到病房或重症监护病房。结果：共有164名患者，平均年龄为47岁（ 18）年（范围：18-97岁）包括83名（50.6％）的女性。 HTQ和HTQ + AZ分别有38和126名患者。在住院5天，所有患者的心率明显较低（P <0.001），而QTC，QT MAX（V5-V6），QTMIN，TP-E（V5-V6）和ICEB值明显高（与在ED中测量的基础值相比，P = 0.01和P <0.001分别为静止（P <0.001）。 HTZ + AZ组的ICEB值明显高于HTQ组（P = 0.03）。 Icebc与TP-E / QT（V5）强烈呈正相关，与TP-E（V5）强烈呈负相关。结论：在Covid-19患者中HTQ和AZ治疗后，ICEB值增加，与TP-E和TP-E / QT强烈相关。 ICEB是一种简单的非侵入性方法，可以是评估Covid-19患者心室复极化的有用标记。

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