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首页> 外文期刊>Journal of surgery and medicine. >Assessment of serum TWEAK levels in patients with familial Mediterranean fever
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Assessment of serum TWEAK levels in patients with familial Mediterranean fever

机译：家庭地中海发烧患者血清调整水平评估

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Background/Aim: Mediterranean fever is an autoinflammatory disease characterized by recurrent attacks. Tumor necrosis factor (TNF) - like weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family, and it has been reported to contribute significantly to the initiation of many inflammatory and immunological processes. In previous studies, an increasing amount of evidence has implicated the participation of TWEAK / Fn14 pathway in the pathogenesis of rheumatic inflammatory diseases that include rheumatoid arthritis, systemic lupus erythematosus and Beh?et's disease. The aim of this study was to investigate the serum TWEAK levels of patients with Familial Mediterranean fever (FMF) and its possible relationship with inflammatory markers and disease activity. Methods: Our study included 20 patients with FMF and 19 healthy volunteers. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) were measured, and PRAS disease severity score was determined in patients with FMF. Also, the FMF attack period was questioned. Serum TWEAK levels were measured with available commercial Enzyme Linked Immunosorbent Assay kits. Results: There was no significant difference in terms of age and gender between the FMF group and the healthy control group (P0.05, for all). ESR, CRP and serum TWEAK levels were significantly higher in patients with FMF (P0.001 for all). PRAS score in FMF patients was 3.4. Serum TWEAK level was not correlated with ESR (r=-0.042, P=0.0801), CRP (r=-0.017 P=0.921), or PRAS score (r=0.247, P=0.149). The ESR and CRP levels of patients in FMF attack period were significantly higher compared to attack free period (P0.001 for both) whereas there was no significant difference in serum TWEAK levels (P=0.686). Conclusions: Serum TWEAK levels are increased in FMF disease with attacks. However, this increase is not associated with increased ESR and CRP during FMF attacks. These results indicate that the TWEAK / Fn14 pathway plays a role in earlier stages where the inflammatory pathways have not differentiated yet. Serum TWEAK levels appear to be more successful in reflecting a lower degree of inflammation compared to ESR and CRP.
机译：背景/目的：地中海发烧是一种自身炎症性疾病，其特征在于经常性攻击。肿瘤坏死因子（TNF） - 凋亡的弱诱导剂（调整）是TNF配体系列的成员，据报道，据据报道，对许多炎症和免疫过程的开始显着贡献。在以前的研究中，越来越多的证据涉及调整/ FN14途径在包括类风湿性关节炎的风湿性炎症疾病的发病机制中的参与，该疾病，Systemic Lupus红斑狼疮和BEP？等疾病。本研究的目的是探讨家庭地中海热（FMF）患者的血清调整水平及其与炎症标志物和疾病活动的可能关系。方法：我们的研究包括20名患有FMF和19名健康志愿者的患者。测量红细胞沉积率（ESR），C反应蛋白（CRP），FMF患者中测定了PRAS疾病严重程度。此外，FMF攻击期被质疑。用可用的商业酶联免疫吸附试剂盒测量血清调节水平。结果：FMF组和健康对照组之间的年龄和性别方面没有显着差异（P＆GT; 0.05）。 FMF患者ESR，CRP和血清调整水平显着较高（P <0.001）。 FMF患者的PRA得分为3.4。血清调整水平与ESR（r = -0.042，p = 0.0801），CRP（r = -0.017 p = 0.921），或pras得分（r = 0.247，p = 0.149）。与攻击自由时期相比，FMF攻击期患者的ESR和CRP水平显着更高（对于两者为0.001），而血清调整水平没有显着差异（P = 0.686）。结论：FMF疾病随着攻击而增加血清调整水平。但是，在FMF攻击期间，这种增加与ESR和CRP增加无关。这些结果表明，Tweak / Fn14途径在早期的阶段起起作用的作用，其中炎性途径尚未区分。与ESR和CRP相比，血清调整水平似乎更成功地反映较低的炎症程度。

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