RTKI-Mediated Reversal of Type 1 Diabetes in NOD Mice by VEGFR-2

Laura Gehl

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RTKI-Mediated Reversal of Type 1 Diabetes in NOD Mice by VEGFR-2

机译：RTEGFR介导的VEGFR-2逆转NOD小鼠的1型糖尿病。

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A cardinal feature of type 1 diabetes (T1D) is damage to pancreatic islets that ultimately results in reduced β-cell mass and hyperglycemia. Improved understanding of the pathways leading to islet cell destruction will offer opportunities to develop new therapeutic targets. In this issue of Diabetes, work from Villalta et al. (p. 2870) in nonobese diabetic (NOD) mice shows that vascular endothelial growth factor receptor 2 (VEGFR-2) is a central target in the receptor tyrosine kinase inhibitor (RTKI)-mediated reversal of T1D. VEGFR, which has various effects on immunity, vascularization, and cell migration, regulates vasculogenesis and angiogenesis primarily through activation of VEGFR-2.

机译：1型糖尿病（T1D）的主要特征是对胰岛的损害，最终导致β细胞量减少和高血糖症。对导致胰岛细胞破坏的途径的进一步了解将为开发新的治疗靶标提供机会。在本期《糖尿病》中，Villalta等人的工作。（p。2870）在非肥胖糖尿病（NOD）小鼠中显示，血管内皮生长因子受体2（VEGFR-2）是受体酪氨酸激酶抑制剂（RTKI）介导的T1D逆转的主要靶标。 VEGFR对免疫，血管生成和细胞迁移具有多种作用，主要通过激活VEGFR-2来调节血管生成和血管生成。

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《Diabetes》 |2013年第8期|2628-2628|共1页
作者
Laura Gehl;
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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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1. Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function [J] . S. Armando Villalta, Jiena Lang, Samantha Kubeck, Diabetes . 2013,第8期

机译：抑制胰岛素抵抗并恢复胰岛功能可抑制VEGFR-2逆转NOD小鼠的1型糖尿病。
2. Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice [J] . Jacques C. Mbongue, Jeffrey Rawson, Pablo A. Garcia, Frontiers in Immunology . 2019,第4期

机译：口服沙门氏菌联合治疗并由调节性T细胞介导的NOD小鼠逆转新发1型糖尿病
3. Synergistic Reversal of Type 1 Diabetes in NOD Mice With Anti-CD3 and Interleukin-1 Blockade Evidence of Improved Immune Regulation [J] . Vitaly Ablamunits, Octavian Henegariu, Jakob Bondo Hansen, Diabetes . 2012,第1期

机译：NOD小鼠中1型糖尿病的协同逆转与抗CD3和白细胞介素1阻断改善免疫调节的证据
4. A biomaterial-based microparticle vaccine reverses type 1 diabetes in NOD mice [C] . Joshua Stewart, Jamal S Lewis, Benjamin G Keselowsky World biomaterials congress . 2016

机译：基于生物材料的微粒疫苗可逆转NOD小鼠的1型糖尿病
5. Reversal of overt type I diabetes in the NOD mouse through the use of combination therapy [D] . Parker, Matthew John. 2008

机译：通过联合疗法逆转NOD小鼠中明显的I型糖尿病
6. Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function [O] . S. Armando Villalta, Jiena Lang, Samantha Kubeck, 2013

机译：抑制胰岛素抵抗并恢复胰岛功能可抑制VEGFR-2逆转NOD小鼠的1型糖尿病。
7. Reversal of New Onset Type 1 Diabetes by Oral Salmonella-Based Combination Therapy and Mediated by Regulatory T-Cells in NOD Mice [O] . Jacques C. Mbongue, Jeffrey Rawson, Pablo A. Garcia, 2019

机译：通过口服沙门氏菌的组合疗法逆转新发起1型糖尿病，并由Nod小鼠的调节T细胞介导
8. Double Negative (CD3+4-8-) TCRalphaBeta Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes [R] . Duncan, B., Nazarov-Stoica, C., Surls, J., 2010

机译：来自年轻NOD小鼠的双阴性（CD3 + 4-8-）TCRalphaBeta脾细胞提供针对1型糖尿病的长期保护

RTKI-Mediated Reversal of Type 1 Diabetes in NOD Mice by VEGFR-2

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