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首页> 外文期刊>Diabetes >A Reduced-Fat Diet and Aerobic Exercise in Japanese Americans With Impaired Glucose Tolerance Decreases Intra-Abdominal Fat and Improves Insulin Sensitivity but not {beta}-Cell Function.
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A Reduced-Fat Diet and Aerobic Exercise in Japanese Americans With Impaired Glucose Tolerance Decreases Intra-Abdominal Fat and Improves Insulin Sensitivity but not {beta}-Cell Function.

机译：葡萄糖耐量受损的日裔美国人的低脂饮食和有氧运动可减少腹部脂肪，并改善胰岛素敏感性，但不能改善β细胞功能。

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摘要

Lifestyle modification reduces the risk of developing type 2 diabetes and may have its effect through improving insulin sensitivity, beta-cell function, or both. To determine whether diet and exercise improve insulin sensitivity and/or beta-cell function and to evaluate these effects over time, we quantified insulin sensitivity and the acute insulin response to glucose (AIRg) in 62 Japanese Americans (age 56.5 +/- 1.3 years; mean +/- SE) with impaired glucose tolerance (IGT) who were randomized to the American Heart Association (AHA) Step 2 diet plus endurance exercise (n = 30) versus the AHA Step 1 diet plus stretching (n = 32) for 24 months. beta-Cell function (disposition index [DI]) was calculated as S(i) x AIRg, where S(i) is the insulin sensitivity index. The incremental area under the curve for glucose (incAUCg) was calculated from a 75-g oral glucose tolerance test. Intra-abdominal fat (IAF) and subcutaneous fat (SCF) areas were measured by computed tomography. At 24 months, the Step 2/endurance group had lower weight (63.1 +/- 2.4 vs. 71.3 +/- 2.9 kg; P = 0.004) and IAF (75.0 +/- 7.9 vs. 112.7 +/- 10.4 cm(2); P = 0.03) and SCF (196.5 +/- 18.0 vs. 227.7 +/- 19.9 cm(2); P < 0.001) areas, greater S(i) (4.7 +/- 0.5 vs. 3.3 +/- 0.3 x 10(-5) min . pmol(-1) . l(-1); P = 0.01), and a trend toward lower AIRg (294.9 +/- 50.0 vs. 305.4 +/- 30.0 pmol/l; P = 0.06) and incAUCg (8,217.3 +/- 350.7 vs. 8,902.0 +/- 367.2 mg . dl(-1) . 2 h(-1); P = 0.08) compared with the Step 1/stretching group after adjusting for baseline values. There was no difference in the DI (P = 0.7) between the groups. S(i) was associated with changes in weight (r = -0.426, P = 0.001) and IAF (r = -0.395, P = 0.003) and SCF (r = -0.341, P = 0.01) areas. Thus, the lifestyle modifications decreased weight and central adiposity and improved insulin sensitivity in Japanese Americans with IGT. However, such changes did not improve beta-cell function, suggesting that this degree of lifestyle modifications may be limited in preventing type 2 diabetes over the long term.
机译：改变生活方式可以降低罹患2型糖尿病的风险，并且可以通过改善胰岛素敏感性，β细胞功能或两者兼而有之。为了确定饮食和运动是否能改善胰岛素敏感性和/或β细胞功能并评估其随时间的影响，我们量化了62位日裔美国人（56.5 +/- 1.3岁）的胰岛素敏感性和对葡萄糖的急性胰岛素反应（AIRg） ；葡萄糖耐量受损（IGT）的平均+/- SE）随机分为美国心脏协会（AHA）第2步饮食加耐力运动（n = 30）和AHA第1步饮食加拉伸（n = 32） 24个月。 β细胞功能（处置指数[DI]）的计算公式为S（i）x AIRg，其中S（i）为胰岛素敏感性指数。葡萄糖曲线下的增量面积（incAUCg）由75克口服葡萄糖耐量试验计算得出。通过计算机体层摄影术测量腹腔内脂肪（IAF）和皮下脂肪（SCF）区域。在第24个月时，第2步/耐力组的体重（63.1 +/- 2.4 vs.71.3 +/- 2.9 kg; P = 0.004）和IAF（75.0 +/- 7.9 vs.112.7 +/- 10.4 cm）较低（2 ）; P = 0.03）和SCF（196.5 +/- 18.0 vs. 227.7 +/- 19.9 cm（2）; P <0.001）面积，更大的S（i）（4.7 +/- 0.5 vs. 3.3 +/- 0.3 x 10（-5）min。pmol（-1）。l（-1）; P = 0.01），并趋向于降低AIRg（294.9 +/- 50.0 vs. 305.4 +/- 30.0 pmol / l; P = 0.06）和incAUCg（8,217.3 +/- 350.7 vs. 8,902.0 +/- 367.2 mg。dl（-1）。2 h（-1）; P = 0.08），与基线调整后的第1步/拉伸组相比。两组之间的DI没有差异（P = 0.7）。 S（i）与体重（r = -0.426，P = 0.001）和IAF（r = -0.395，P = 0.003）和SCF（r = -0.341，P = 0.01）面积的变化有关。因此，在IGT的日裔美国人中，生活方式的改变减少了体重和中枢性肥胖，并改善了胰岛素敏感性。但是，这种改变并不能改善β细胞功能，这表明这种生活方式的改变在长期预防2型糖尿病方面可能受到限制。

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