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首页> 外文期刊>Diabetes >Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Is Associated With Increased Levels of Coronary Heart Disease Risk Factors: Results From the Baltimore Longitudinal Study on Aging.
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Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Is Associated With Increased Levels of Coronary Heart Disease Risk Factors: Results From the Baltimore Longitudinal Study on Aging.

机译：葡萄糖耐量减低但空腹血糖未减退与冠心病危险因素水平增高相关：巴尔的摩关于衰老的纵向研究的结果。

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摘要

Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) identify individuals at high risk for progression to diabetes. Whether IFG and IGT have comparable coronary heart disease (CHD) risk factor profiles, independent of their progression to diabetes, is unclear. We determined CHD risk factor levels in 937 nondiabetic individuals at baseline and biannually over a mean follow-up period of 9.5 years. Subjects had no known CHD at baseline and had >/=2 (mean 4.2) oral glucose tolerance tests during follow-up. We classified glucose tolerance categories using American Diabetes Association diagnostic criteria or modified criteria that redefined IFG as 100-126 mg/dl, creating a similar baseline prevalence of IFG and IGT. Subjects who developed diabetes during follow-up were excluded from our analysis. Baseline CHD risk factors were similar in subjects with normal glucose tolerance (NGT) and IFG, but significantly more atherogenic in those with IGT or IFG + IGT. These findings were unchanged when the modified criteria were used, suggesting that IGT is phenotypically different from IFG and is associated with increased levels of CHD risk factors. Subjects with isolated IFG had similar levels of CHD risk factors as NGT subjects, even when IFG was redefined with a lower threshold. Although CHD risk factors were increased in the IGT group, the incidence of CHD events was not significantly different among groups, perhaps owing to the limited number of events. The differences in CHD risk factors among prediabetic groups may have clinical implications for screening strategies and CHD risk stratification of individuals with IFG and IGT.
机译：空腹血糖（IFG）受损和葡萄糖耐量（IGT）受损可识别出罹患糖尿病的高风险人群。尚不清楚IFG和IGT是否具有可比的冠心病（CHD）危险因素概况，而与他们的糖尿病进展无关。我们在9.5年的平均随访期内，确定了937名非糖尿病患者的基线和半年度CHD危险因素水平。受试者在基线时没有已知的冠心病，并且在随访期间进行了≥2的口服葡萄糖耐量测试（平均值4.2）。我们使用美国糖尿病协会的诊断标准或修改后的标准（将IFG重新定义为100-126 mg / dl）对葡萄糖耐量类别进行了分类，从而创建了类似的IFG和IGT基线患病率。随访期间发生糖尿病的受试者被排除在我们的分析之外。葡萄糖耐量正常（NGT）和IFG的受试者的基线冠心病危险因素相似，但IGT或IFG + IGT的受试者的动脉粥样硬化发生率明显更高。当使用修改的标准时，这些发现没有改变，表明IGT在表型上与IFG不同，并且与CHD危险因素水平升高有关。即使将IFG重新定义为较低的阈值，具有孤立IFG的受试者的CHD危险因素水平也与NGT受试者相似。尽管IGT组中CHD危险因素增加，但是各组中CHD事件的发生率并没有显着差异，这可能是由于事件数量有限所致。糖尿病前组中CHD危险因素的差异可能对IFG和IGT个体的筛查策略和CHD危险分层具有临床意义。

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