LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat

J. L. Figarola; S. Loera; Y. Weng; N. Shanmugam; R. Natarajan; S. Rahbar

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LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat

机译：LR-90可预防Zucker糖尿病脂肪大鼠的血脂异常和糖尿病肾病

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Aims/hypothesis Previous studies have shown that LR-90, a new inhibitor of AGE formation, prevented the development of experimental type 1 diabetic nephropathy. In this study, we examined the effects of LR-90 in the Zucker diabetic fatty (ZDF) rat, a model of type 2 diabetes and metabolic syndrome, and investigated the mechanisms by which it may protect against renal injury.

机译：目的/假设先前的研究表明，LR-90是AGE形成的新抑制剂，它阻止了实验性1型糖尿病肾病的发展。在这项研究中，我们检查了LR-90对Zucker糖尿病脂肪（ZDF）大鼠（一种2型糖尿病和代谢综合征的模型）的作用，并研究了其可能预防肾脏损伤的机制。

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《Diabetologia》 |2008年第5期|p.882-891|共10页
作者
J. L. Figarola; S. Loera; Y. Weng; N. Shanmugam; R. Natarajan; S. Rahbar;
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正文语种 eng
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AGE inhibition; Diabetic nephropathy; Dyslipidaemia; Extracellular matrix; Glomerulosclerosis; Glycation; Oxidative stress; Renal fibrosis; Renal protection; Type 2 diabetes;

机译：AGE抑制;糖尿病肾病;血脂异常;细胞外基质;肾小球硬化;糖基化;氧化应激;肾纤维化;肾脏保护;2型糖尿病;

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1. KIOM-79, an Inhibitor of AGEs–Protein Cross-linking, Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats [J] . Young SookKim, JunghyunKim, Chan-SikKim, Evidence-based complementary and alternative medicine: eCAM . 2011,第2期

机译：KIOM-79是AGEs-蛋白质交联的抑制剂，可预防Zucker糖尿病肥胖大鼠的肾病进展
2. Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats [J] . Giovanna Castoldi, Cira R. T. di Gioia, Camila Bombardi, American Journal of Physiology . 2014,第5aPta2期

机译：通过化合物21预防糖尿病肾病，在Zucker糖尿病脂肪大鼠中的血管紧张素2型受体的选择性激动剂
3. Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats [J] . Jorge F. Giani, Valeria Burghi, Luciana C. Veiras, American Journal of Physiology . 2012,第6aPta2期

机译：血管紧张素-（1-7）减轻Zucker糖尿病高脂大鼠的糖尿病肾病
4. Swallow nest extract can be able to prevent nephropathy diabetic of the white rats streptozotocin-induced [C] . T Triawanti, F D Alexandra, A Frethernity, International Seminar on Smart Molecule of Natural Resources . 2020

机译：燕窝巢提取物可以能够防止白鼠肾病糖尿病链脲佐菌素诱导的
5. The use of intestinal microflora modification to maximize the anti-obesity and anti-diabetic effects of soy protein diets in female Zucker diabetic fatty rats. [D] . Martin, Michele Marie. 2008

机译：肠道菌群修饰的使用可最大程度地提高雌性Zucker糖尿病脂肪大鼠的大豆蛋白饮食的抗肥胖和抗糖尿病作用。
6. KIOM-79 an Inhibitor of AGEs–Protein Cross-linking Prevents Progression of Nephropathy in Zucker Diabetic Fatty Rats [O] . Young Sook Kim, Junghyun Kim, Chan-Sik Kim, 2011

机译：KIOM-79是AGEs-蛋白质交联抑制剂可预防Zucker糖尿病肥胖大鼠的肾病进展
7. LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats [O] . S. Scott, S. Loera, C. Tessler, 2003

机译：LR-90新的高级糖化封端抑制剂可防止糖尿病 - 糖尿病大鼠中糖尿病肾病的进展

LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker diabetic fatty rat

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