首页> 外文期刊>Diabetologia >Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli
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Glomerular expression of thrombospondin-1, transforming growth factor beta and connective tissue growth factor at different stages of diabetic nephropathy and their interdependent roles in mesangial response to diabetic stimuli

机译:糖尿病肾病不同时期血小板反应蛋白-1,转化生长因子β和结缔组织生长因子的肾小球表达及其在肾小球系膜反应中的相互依赖性

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摘要

We quantified the glomerular expression of thrombospondin-1 (THBS1, also known as TSP-1), transforming growth factor beta 1 (TGFB1, also known as TGF-β1) and connective tissue growth factor (CTGF) at each stage of diabetic nephropathy. We also examined the roles of THBS1 and CTGF in mediating high-glucose- and glycated-albumin-induced synthesis of the matrix protein, fibronectin, by mesangial cells.
机译:我们对糖尿病肾病各个阶段的血小板反应蛋白-1(THBS1,也称为TSP-1),转化生长因子β1(TGFB1,也称为TGF-β1)和结缔组织生长因子(CTGF)的肾小球表达进行了定量。我们还检查了THBS1和CTGF在介导肾小球膜细胞介导的高糖和糖化白蛋白诱导的基质蛋白纤连蛋白合成中的作用。

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