...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Digestive Diseases and Sciences >Association between Proton Pump Inhibitor Use and Spontaneous Bacterial Peritonitis
【24h】

Association between Proton Pump Inhibitor Use and Spontaneous Bacterial Peritonitis

机译：质子泵抑制剂的使用与自发性细菌性腹膜炎之间的关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Proton pump inhibitors (PPIs) increase enteric bacterial colonization, overgrowth, and translocation, all effects which might predispose to spontaneous bacterial peritonitis. We investigated whether PPI usage is associated with spontaneous bacterial peritonitis. Our retrospective case-control study included 116 consecutive cirrhotic patients with ascites who underwent diagnostic paracentesis upon hospital admission (2002–2005). Spontaneous bacterial peritonitis was defined as paracentesis yielding ≥250 polymorphonuclear leukocytes/ml. We performed logistic regression to determine the risk of spontaneous bacterial peritonitis by PPI usage. Of the 116 subjects, 32 had spontaneous bacterial peritonitis. Patient characteristics were similar between groups with and without infection, with the exception of the Model for End-Stage Liver Disease score (median: 23 and 18, respectively; P = 0.002). Crude and adjusted odds ratios for the development of spontaneous bacterial peritonitis by exposure to PPIs were 1.22 (95% confidence interval: 0.52–2.87) and 1.05 (0.43–2.57), respectively. In conclusion, we did not find a positive association between PPI use and spontaneous bacterial peritonitis.
机译：质子泵抑制剂（PPI）会增加肠道细菌的定植，过度生长和易位，所有这些作用都可能导致自发性细菌性腹膜炎。我们调查了PPI的使用是否与自发性细菌性腹膜炎有关。我们的回顾性病例对照研究包括116例连续性肝硬化腹水患者，他们在入院时接受了诊断性穿​​刺术（2002-2005年）。自发性细菌性腹膜炎的定义是穿刺穿刺术产生≥250个多形核白细胞/ ml。我们进行了逻辑回归分析，以通过使用PPI来确定自发性细菌性腹膜炎的风险。在116名受试者中，有32名患有自发性细菌性腹膜炎。除有终末期肝病模型得分（中位数分别为23和18； P = 0.002）外，有和没有感染的组之间的患者特征相似。通过暴露于PPI引起的自发性细菌性腹膜炎的原始和调整后的优势比分别为1.22（95％置信区间：0.52-2.87）和1.05（0.43-2.57）。总之，我们没有发现使用PPI与自发性细菌性腹膜炎之间存在正相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号