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首页> 外文期刊>Digestive Diseases and Sciences >Electroacupuncture at Acupoint ST-36 Promotes Contractility of Distal Colon via a Cholinergic Pathway in Conscious Rats
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Electroacupuncture at Acupoint ST-36 Promotes Contractility of Distal Colon via a Cholinergic Pathway in Conscious Rats

机译：针刺ST-36穴位电刺激通过清醒大鼠胆碱能途径促进远端结肠的收缩力

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Purpose To investigate the effects and possible mechanism of electroacupuncture (EA) at acupoint ST-36 (Zusanli) on the contractility of the distal colon in conscious rats. Methods Rats were randomized into four groups, including the ST-36 group, the sham group, the saline-plus-ST-36 and the atropine-plus-ST-36 group. Needles were inserted into the acupoints for EA. The distal colonic contractility was measured with a manometric catheter inserted into the distal colon. The colonic contractility was recorded for 1 h before EA, 20 min during EA, and 3 h after EA. Saline or atropine was administrated in the saline-plus-ST-36 or atropine-plus-ST-36 group. Results (1) EA at ST-36 significantly increased the contractility of the distal colon. The mean AUC during and after EA were significantly higher than that before EA in the ST-36 group, a 27% increase during EA and 26% after EA. (2) Atropine abolished the accelerating effect of EA at ST-36. The mean AUC remained unchanged during or after EA compared with that before EA in the atropine-plus-ST-36 group. Conclusions EA at ST-36 has a stimulatory effect on the contractility of the distal colon in conscious rats, and the stimulatory effect may be mediated via the cholinergic pathway.
机译：目的研究穴位ST-36（足三里）电针（EA）对清醒大鼠远端结肠收缩力的影响及其可能的机制。方法将大鼠随机分为四组，分别为ST-36组，假手术组，生理盐水加ST-36组和阿托品加ST-36组。将针插入EA的穴位。用插入远端结肠的测压导管测量远端结肠收缩力。在EA之前1小时，EA期间20分钟和EA之后3小时记录结肠收缩力。生理盐水加ST-36或阿托品加ST-36组给予盐水或阿托品。结果（1）ST-36的EA显着增加了远端结肠的收缩力。在ST-36组中，EA期间和之后的平均AUC均显着高于EA之前的水平，EA期间增加了27％，EA之后增加了26％。 （2）阿托品取消了ST-36 EA的加速作用。与阿托品加ST-36组的EA相比，EA期间或之后的平均AUC保持不变。结论ST-36的EA对清醒大鼠远端结肠的收缩有刺激作用，其刺激作用可能是通过胆碱能途径介导的。

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