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首页> 外文期刊>Digestive Diseases and Sciences >The Effect of Opioids on the Development of Postoperative Intra-Abdominal Adhesions
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The Effect of Opioids on the Development of Postoperative Intra-Abdominal Adhesions

机译：阿片类药物对术后腹腔粘连发展的影响

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People addicted to opium rarely develop intra-abdominal adhesions after abdominal surgery. We aimed to evaluate the effect of opium or morphine on preventing postoperative adhesions in rats. Sixty-three rats were randomly divided into a control group, opium-addicted group, and morphine-addicted group in a double-blind study. Drug dependency was checked by using naloxone. Animals were then operated on and the cecum was abraded. At reoperation 3 weeks later the magnitude of adhesions was evaluated by a scoring system. There was a significant difference between the control, opium-addicted, and morphine-addicted groups with regard to the length (P < .001), thickness (P < .05), and severitadhesions (P < .05). Opium or morphine reduces the severitpostoperative adhesions. Elucidation of the opioid receptor(s) involved in this process would enable the use of selective ligands and offer a pharmacologic strategy in preventing adhesion formation.
机译：对鸦片上瘾的人在腹部手术后很少发生腹部内粘连。我们旨在评估鸦片或吗啡对预防大鼠术后粘连的作用。在双盲研究中，将六十三只大鼠随机分为对照组，鸦片成瘾组和吗啡成瘾组。通过使用纳洛酮检查药物依赖性。然后对动物进行手术，并切除盲肠。在3周后的再次手术中，通过评分系统评估粘附的程度。对照组，鸦片组和吗啡组在长度（P <.001），厚度（P <.05）和严重粘连（P <.05）方面有显着差异。鸦片或吗啡可减轻术后严重粘连。阐明参与该过程的阿片样物质受体将使得能够使用选择性配体并提供防止粘连形成的药理学策略。

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