Acid-Suppressive Efficacy of a Reduced Dosage of Rabeprazole: Comparison of 10 Mg Twice Daily Rabeprazole with 20 Mg Twice Daily Rabeprazole, 30 Mg Twice Daily Lansoprazole, and 20 Mg Twice Daily Omeprazole by 24-Hr Intragastric pH-metry

Tomohiko Shimatani MD; Masaki Inoue MD; Tomoko Kuroiwa RN; Jing Xu MD; Susumu Tazuma MD; Yoko Horikawa MD; Masuo Nakamura MD

首页> 外文期刊>Digestive Diseases and Sciences >Acid-Suppressive Efficacy of a Reduced Dosage of Rabeprazole: Comparison of 10 Mg Twice Daily Rabeprazole with 20 Mg Twice Daily Rabeprazole, 30 Mg Twice Daily Lansoprazole, and 20 Mg Twice Daily Omeprazole by 24-Hr Intragastric pH-metry

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Acid-Suppressive Efficacy of a Reduced Dosage of Rabeprazole: Comparison of 10 Mg Twice Daily Rabeprazole with 20 Mg Twice Daily Rabeprazole, 30 Mg Twice Daily Lansoprazole, and 20 Mg Twice Daily Omeprazole by 24-Hr Intragastric pH-metry

机译：雷贝拉唑剂量减少的酸抑制功效：通过24小时胃内pH值测定法比较每日10毫克两次雷贝拉唑与每日20毫克两次雷贝拉唑，每日30毫克两次兰索拉唑和每天20毫克奥美拉唑。

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摘要

Rabeprazole achieves more potent acid suppression than other proton pump inhibitors. Therefore it is administered at reduced as well as high dosages in eradication therapy for Helicobacter pylori; however, there is incomplete assessment of the efficacy of a reduced dosage of rabeprazole as might be employed in therapy.

机译：雷贝拉唑比其他质子泵抑制剂具有更强的抑酸能力。因此，它在幽门螺杆菌的根除治疗中以低剂量和高剂量给药。然而，对减少剂量的雷贝拉唑的疗效（如可用于治疗）的评估尚不完全。

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来源
《Digestive Diseases and Sciences》 |2005年第7期|1202-1206|共5页
作者
Tomohiko Shimatani MD; Masaki Inoue MD; Tomoko Kuroiwa RN; Jing Xu MD; Susumu Tazuma MD; Yoko Horikawa MD; Masuo Nakamura MD;
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作者单位

Department of General Medicine Hiroshima University Hospital;

Department of Geriatric Health Sciences Graduate School of Health Sciences Hiroshima University;

Department of Geriatric Health Sciences Graduate School of Health Sciences Hiroshima University;

Department of Geriatric Health Sciences Graduate School of Health Sciences Hiroshima University;

Department of General Medicine Hiroshima University Hospital;

Department of Internal Medicine Medical Co. Kouwakai Eastern Examination Center;

Department of Internal Medicine Wakasagi Medical Clinic;

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原文格式 PDF
正文语种 eng
中图分类
关键词
rabeprazole; Helicobacter pylori; cytochrome P-450 2C19; extensive metabolizer; intragastric pH;

机译：雷贝拉唑;幽门螺杆菌;细胞色素P-450 2C19;广泛代谢者;胃内pH;

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专利

1. Rabeprazole, 20 mg once daily or 10 mg twice daily, is equivalent to omeprazole, 20 mg once daily, in the healing of erosive gastrooesophageal reflux disease. [J] . Delchier JC, Cohen G, Humphries TJ Scandinavian journal of gastroenterology. . 2000,第12期

机译：雷贝拉唑，每天一次20毫克或每天两次10毫克，相当于糜烂性胃食管反流疾病的治愈，每天一次奥美拉唑20毫克。
2. Acid-suppressive effects of rabeprazole: comparing 10mg and 20mg twice daily in Japanese Helicobacter pylori-negative and -positive CYP2C19 extensive metabolisers. [J] . Shimatani T, Moriwaki M, Xu J, Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver . 2006,第11期

机译：雷贝拉唑的抑酸作用：比较日本幽门螺杆菌阴性和阳性CYP2C19广泛代谢者中每日两次10mg和20mg。
3. Dose-response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes. [J] . Seiichi Hayato, Setsuo Hasegawa, Seiichiro Hojo, European journal of clinical pharmacology . 2012,第5期

机译：在具有不同CYP2C19基因型的健康日本个体中，雷贝拉唑5、10、20和40 mg每天一次抑制通宵通宵的胃酸分泌的剂量反应关系。
4. Sub-daily extreme events distribution and changes in Northeastern Brazil in the 20th century [C] . R. Basso, D. Allasia, R. Tassi, . 2015

机译：20世纪巴西东北部次日极端事件的分布和变化
5. A Shifting Island Landscape: Changes in Land Use and Daily Life in the 19th and 20th Century Village of Inishark, Co. Galway, Ireland [D] . Couey, Lauren. 2018

机译：一个震动的岛屿景观：19世纪Inishark，Co.Carway，Ireland的土地利用和日常生活的变化
6. A Multicenter Randomized Open-Label Trial: Efficacy of Once-Daily Versus Twice-Daily Double-Dose Rabeprazole on Refractory Gastroesophageal Reflux Disease-Related Symptoms and Quality of Life [O] . Akira Mizuki, Masayuki Tatemichi, Terue Sakakibara, 2016

机译：一项多中心随机开放标签的试验：每日一次与每日两次双剂量雷贝拉唑对难治性胃食管反流疾病相关症状和生活质量的疗效
7. Comparison of rabeprazole 20 mg vs. omeprazole 20 mg in the treatment of active gastric ulcer--a European multicentre study. The European Rabeprazole Study Group [O] . Dekkers, C P, Beker, J A, Thjodleifsson, B, 1998

机译：欧洲多中心研究比较雷贝拉唑20 mg和奥美拉唑20 mg治疗活动性胃溃疡的比较。欧洲雷贝拉唑研究小组

Acid-Suppressive Efficacy of a Reduced Dosage of Rabeprazole: Comparison of 10 Mg Twice Daily Rabeprazole with 20 Mg Twice Daily Rabeprazole, 30 Mg Twice Daily Lansoprazole, and 20 Mg Twice Daily Omeprazole by 24-Hr Intragastric pH-metry

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