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首页> 外文期刊>Digestive Diseases and Sciences >Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats
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Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats

机译：黄酮类，卵黄素对乙醇诱发的大鼠胃黏膜损伤的预防作用

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摘要

Whether wogonin (5,7-dihydroxy-8-methoxyflavone), a flavonoid originated from the root of Scutellaria baicalensis Georgi, which has been shown to have antiinflammatory and antitumor activities in various cell types, possesses a gastric cytoprotective effect was investigated in an ethanol-induced gastric damage model in rats. Ethanol administration alone induced evident gastric damage including gastric hemorrhages and edema, while this gastric damage was significantly attenuated by wogonin pretreatment (30 mg/kg B.W.) 1 hr before ethanol administration. As major protective mechanisms of wogonin on ethanol-induced gastric damage, we found that wogonin showed either antiinflammatory effects through dual actions on arachidonic acid metabolism, i.e., induction of prostaglandin D2 and suppression of 5S-hydroxyeicosatetraenoic acid (5S-HETE), or preventive induction of profuse apoptosis in the stomach. Conclusively, the flavonoid wogonin could be used as a preventive agent of alcohol-induced gastropathy, whose actions were proven to be strong antiinflammation and apoptosis induction.
机译：在乙醇中研究了wogonin（5,7-dihydroxy-8-methoxyflavone），一种来自黄the根的黄酮是否已显示出在各种细胞类型中的抗炎和抗肿瘤活性，是否具有胃细胞保护作用。诱导的大鼠胃损伤模型。单独服用乙醇会引起明显的胃损伤，包括胃出血和水肿，而在服用乙醇前1小时，用卵黄素预处理（30 mg / kg体重）可明显减轻这种胃损伤。作为伍格宁对乙醇引起的胃损伤的主要保护机制，我们发现伍格宁通过对花生四烯酸代谢的双重作用（即诱导前列腺素D2 和抑制5S-羟基二十碳四烯酸（5S-HETE）显示出抗炎作用），或预防性诱导胃中大量凋亡。结论是，类黄酮wogonin可以用作酒精性胃病的预防剂，其作用被证明具有很强的抗发炎和凋亡诱导作用。

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  • 来源
    《Digestive Diseases and Sciences》 |2004年第3期|384-394|共11页
  • 作者

    Soojin Park; Ki-Baik Hahm; Tae-Young Oh; Joo-Hyun Jin; Ryowon Choue;

  • 作者单位

    Department of Medical Nutrition Graduate School of East-West Medical Science Kyung Hee UniversityGenomic Research Center for Gastroenterology Ajou University School of Medicine;

    Genomic Research Center for Gastroenterology Ajou University School of Medicine;

    Genomic Research Center for Gastroenterology Ajou University School of Medicine;

    Genomic Research Center for Gastroenterology Ajou University School of Medicine;

    Department of Medical Nutrition Graduate School of East-West Medical Science Kyung Hee University;

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  • 正文语种 eng
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  • 关键词

    gastric mucosal damage; ethanol; wogonin; COX; PGD2; apoptosis;

    机译：胃粘膜损伤;乙醇;伍格宁;COX;PGD2;细胞凋亡;

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