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首页> 外文期刊>Digestive Diseases and Sciences >Immunomodulatory Effects of Granulocyte and Monocyte Adsorption Apheresis as a Treatment for Patients with Ulcerative Colitis
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Immunomodulatory Effects of Granulocyte and Monocyte Adsorption Apheresis as a Treatment for Patients with Ulcerative Colitis

机译：粒细胞和单核细胞吸附黏附的免疫调节作用对溃疡性结肠炎的治疗

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Our aim was to understand the mechanism of immunological changes associated with the use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for selective adsorption of granulocytes and monocytes/macrophages from peripheral blood of patients with active ulcerative colitis. The column is filled with carriers (G-1 beads) that have a diameter of 2 mm and are made of cellulose diacetate. In peripheral blood treated with the G-1 beads or peripheral blood from patients with active ulcerative colitis following granulocyte and monocyte adsorption apheresis, a significant suppression of proinflammatory cytokines (tissue necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-8) production by leukocytes, neutrophil chemotaxis, down-regulation of leukocyte adhesion molecule (L-selectin) and neutrophil adhesion to interleukin-1β-activated endothelial cells were observed. Furthermore, after granulocyte adsorption therapy, the number of CD10-negative premature granulocytes increased, indicating increased turnover of these cells in the circulation. Our observations suggest that selective granulocyte and monocyte adsorption is associated with modified peripheral blood leukocyte function favorable to patients with ulcerative colitis and possibly other autoimmune disorders which reflect leukocyte hyperactivity.
机译：我们的目的是了解与使用吸附型体外装置（Adacolumn）相关的免疫学改变的机制，该装置已被开发用于选择性吸收活动性溃疡性结肠炎患者外周血中的粒细胞和单核细胞/巨噬细胞。该柱填充有直径为2 mm的载体（G-1珠），由二乙酸纤维素制成。在用G-1珠子治疗的外周血或来自粒细胞和单核细胞吸附单采的活动性溃疡性结肠炎患者的外周血中，促炎性细胞因子（组织坏死因子-α，白介素-1β，白介素-6和白介素- 8）观察到白细胞产生，嗜中性粒细胞趋化性，白细胞粘附分子（L-选择素）的下调和嗜中性粒细胞对白介素-1β活化的内皮细胞的粘附。此外，在粒细胞吸附疗法之后，CD10阴性的早粒细胞的数量增加，表明这些细胞在循环中的周转率增加。我们的观察结果表明，选择性粒细胞和单核细胞的吸附与外周血白细胞功能的改善有关，有利于溃疡性结肠炎以及可能反映白细胞过度活跃的其他自身免疫性疾病的患者。

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