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首页> 外文期刊>Digestive Diseases and Sciences >Lovastatin Alters Biliary Lipid Composition and Dissolves Gallstones: A Long-Term Study in Prairie Dogs
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Lovastatin Alters Biliary Lipid Composition and Dissolves Gallstones: A Long-Term Study in Prairie Dogs

机译：洛伐他汀改变胆汁脂质成分并溶解胆结石：草原犬的长期研究

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Lovastatin, an inhibitor of the rate-limiting enzyme in cholesterol biosynthesis, is widely used to treat hypercholesterolemia. We investigated the long-term effects of lovastatin alone and in combination with ursodeoxycholic acid on biliary lipid composition and gallstone dissolution. Forty-two prairie dogs were fed 1.2% cholesterol diet for 5 weeks, and cholecystectomy was performed on 6 animals to confirm gallstones. The remaining animals were maintained on a 0.4% cholesterol diet and were randomized to receive placebo, lovastatin (3.3 mg/g diet), ursodeoxycholic acid (10 mg/g), or combination of both drugs. After 10 weeks, animals underwent cholecystectomy. Dissolution response to therapy was determined, and serum and biliary lipids were measured. All treatment groups had significant reductions in serum cholesterol. Lovastatin treatment reduced both hepatic and gallbladder bile cholesterol, altered bile acid composition, and induced a 79% total response compared to placebo. Although ursodeoxycholic treatment induced a 44% response, long-term combination treatment elevated both gallbladder bile cholesterol and calcium and failed to produce an augmented response. These data suggest that lovastatin therapy alone may promote gallstone dissolution in humans.
机译：洛伐他汀是胆固醇生物合成中限速酶的抑制剂，被广泛用于治疗高胆固醇血症。我们研究了洛伐他汀单独和与熊去氧胆酸联合对胆汁脂质成分和胆结石溶解的长期影响。 42只草原犬饲喂1.2％的胆固醇，持续5周，对6只动物进行了胆囊切除术以确认胆结石。其余动物维持0.4％的胆固醇饮食，并随机接受安慰剂，洛伐他汀（3.3 mg / g饮食），熊去氧胆酸（10 mg / g）或两种药物的组合。 10周后，对动物进行胆囊切除术。确定对治疗的溶解反应，并测量血清和胆脂。所有治疗组的血清胆固醇均明显降低。与安慰剂相比，洛伐他汀治疗可降低肝脏和胆囊胆汁胆固醇，改变胆汁酸成分，并引起79％的总反应。尽管熊去氧胆酸治疗可引起44％的反应，但长期联合治疗可升高胆囊胆汁胆固醇和钙，但未能产生增强的反应。这些数据表明，单独的洛伐他汀治疗可能会促进胆结石在人体内的溶解。

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