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Lack of Objective Evidence of Efficacy of Laxatives in Chronic Constipation

机译：在慢性便秘中缺乏泻药功效的客观证据

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Laxatives are commonly used to treat constipation and can be bought over-the-counter in many countries, although some preparations need to be prescribed by physicians. A meta-analysis was conducted to quantitatively evaluate the published evidence on the efficacy of laxatives in constipation. We found that large, well-controlled, published studies whose data were comparable were lacking. Of 250 articles, 35 met the inclusion criteria but only 11 yielded usable data (N = 375 patients on laxatives, 174 on placebo). There was an effect of laxatives on stool frequency (mean increase 1.9 stools per week) and stool weight (mean increase 476 g) but this was not clearly distinguishable from that of placebo therapies (1 stool and 434 g, respectively) in studies up to 4 weeks in duration. Similarly, studies of 5–12 weeks yielded no differences overall. These results cannot definitively rule out laxatives as an effective treatment, due to the poor published evidence. Better evidence is required to justify the continued expenditure of funds on laxatives by both patients and formularies.
机译：泻药通常用于治疗便秘，并且在许多国家可以通过非处方药购买，尽管有些制剂需要医生处方。进行了荟萃分析，以定量评估已发表的泻药对便秘功效的证据。我们发现，缺乏数据可比的，控制良好的大型出版研究。在250篇文章中，有35篇符合入选标准，但只有11篇提供了可用数据（使用泻药的N = 375例患者，使用安慰剂的174例）。轻泻剂对大便次数（平均每周增加1.9个大便）和大便重量（平均增加476 g）有影响，但是直到研究为止，这与安慰剂疗法（分别为1个大便和434 g）没有明显区别。持续4周。同样，5-12周的研究总体上没有差异。由于发表的证据不充分，这些结果不能明确排除泻药是一种有效的治疗方法。需要有更好的证据来证明患者和处方药持续在泻药上的支出是合理的。

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