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Age- and Diet-Related Increase in Transepithelial Colon Permeability of Fischer 344 Rats

机译：Fischer 344大鼠经上皮结肠通透性与年龄和饮食相关的增加

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摘要

When transepithelial permeability of rat distal colon is evaluated on the basis of transepithelial electrical resistance, age does not have an effect. Age likewise did not affect the decrease in resistance brought about by phorbol ester exposure. However, age was shown to correlate with increased transepithelial permeability when diffusion of the nonelectrolyte, d-mannitol, was used as an indicator. A phorbol ester-induced increase in transepithelial permeability to d-mannitol was observed to increase with age. Basal permeability to d-mannitol was significantly higher in older rats when the animals were allowed to age on a high-fat diet. Distance from the rectum was shown to be a potential complicating factor in these studies, since distal colon closer to the rectum was observed to have lower transepithelial permeability. The potential effect of such increased leakiness on the increased frequency of colon cancer in older individuals is discussed.
机译：当基于跨上皮电阻评估大鼠远端结肠的跨上皮通透性时，年龄没有影响。年龄同样不影响佛波醇酯暴露引起的抵抗力下降。但是，当非电解质d-甘露醇的扩散用作指标时，年龄与上皮通透性增加相关。观察到佛波酯诱导的对d-甘露醇的跨上皮通透性的增加随年龄增加。当允许高脂饮食使动物衰老时，其对d-甘露醇的基础通透性明显更高。在这些研究中，距直肠的距离被证明是一个潜在的复杂因素，因为观察到靠近直肠的远端结肠的上皮通透性较低。讨论了这种泄漏增加对老年人结肠癌发生频率增加的潜在影响。

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