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首页> 外文期刊>Digestive Diseases and Sciences >Hepatocyte Growth Factor Expression in Dextran Sodium Sulfate-Induced Colitis in Rats
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Hepatocyte Growth Factor Expression in Dextran Sodium Sulfate-Induced Colitis in Rats

机译：葡聚糖硫酸钠诱导的大鼠结肠炎中肝细胞生长因子的表达

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摘要

Hepatocyte growth factor (HGF), a potent inducer of cell migration with morphogenic and mitogenic actions was reported to have key roles in the repair of various tissues. In order to evaluate the role of HGF in the repair process of inflammatory bowel disease, we have investigated the HGF expression in a dextran sodium sulfate (DSS) colitis model. We randomly assigned rats to a colitis group or to a placebo group; the former received a 7-day course of 5% DSS (mw 5 kDa) in drinking water. DSS-induced severe colitis in rats manifested with weight loss, diarrhea, and intestinal bleeding. Animals were killed from day 1 through 7 and on days 9 and 14 after the end of DSS administration. After DSS was withdrawn, disease activity subsided gradually and HGF expression was significantly enhanced along with the augmented expression of IL-1β, TNF-α, and cyclooxygenase-2, accompanied by an increased number of proliferating epithelial cells in colon. These findings suggest that proinflammatory cytokines and cyclooxygenase-2 may have an important role in the mucosal repair in inflammatory bowel disease through increased production of HGF.
机译：据报道，肝细胞生长因子（HGF）是具有形态发生和促有丝分裂作用的细胞迁移的有效诱导剂，在各种组织的修复中具有关键作用。为了评估HGF在炎症性肠病修复过程中的作用，我们研究了葡聚糖硫酸钠（DSS）结肠炎模型中HGF的表达。我们将大鼠随机分为结肠炎组或安慰剂组。前者在饮用水中接受了为期7天的5％DSS（mw 5 kDa）疗程。 DSS诱导的大鼠严重结肠炎表现为体重减轻，腹泻和肠道出血。从DSS给药结束后的第1天至第7天以及第9天和第14天处死动物。撤回DSS后，疾病活动逐渐消退，HGF表达随着IL-1β，TNF-α和环氧合酶-2的表达增加而显着增强，伴随结肠中上皮细胞的增殖。这些发现表明促炎细胞因子和环氧合酶-2可能通过增加HGF的产生在炎症性肠病的粘膜修复中起重要作用。

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