Stem Cells Make Insulin, Restore Retinas

JEFF WHEELWRIGHT

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Stem Cells Make Insulin, Restore Retinas

机译：干细胞制造胰岛素，恢复视网膜

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Since embryonic stem cells were first cultured in the lab more than 30 years ago, researchers have talked up their therapeutic potential. Able to differentiate into dozens of tissue types, stem cells might be used to regenerate organs and treat numerous diseases. The proof has been slow to come, however. "You've been hearing about them for decades, but where's the beef?" asks Robert Lanza, chief scientist at Advanced Cell Technology and a pioneer of regenerative medicine. The field has been dogged by political and religious opponents, who object to the destruction of human embryos during the harvest of cells.

机译：自从30年前在实验室中首次培养出胚胎干细胞以来，研究人员就开始谈论其治疗潜力。干细胞能够分化成数十种组织类型，可用于再生器官并治疗多种疾病。但是，证据来得很慢。 “你几十年来一直在听说它们，但是牛肉在哪里？”高级细胞技术首席科学家，再生医学的先驱罗伯特·兰扎（Robert Lanza）问道。政治和宗教的反对者一直在争夺这个领域，他们反对在收集细胞的过程中破坏人类胚胎。

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《Discover》 |2015年第1期|24-24|共1页
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JEFF WHEELWRIGHT;
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1. Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1 [J] . Lei L. -T., Chen J. -B., Zhao Y. -L., European review for medical and pharmacological sciences. . 2016,第6期

机译：白藜芦醇可减轻脂肪间充质干细胞的衰老并恢复其旁分泌对通过Pim-1促进INS-1细胞胰岛素分泌的作用
2. Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1 [J] . L.-T. Lei, J.-B. Chen, Y.-L. Zhao, European review for medical and pharmacological sciences. . 2016,第6期

机译：白藜芦醇可减轻脂肪间充质干细胞的衰老并恢复其旁分泌对通过Pim-1促进INS-1细胞胰岛素分泌的作用
3. Mesenchymal stem cells expressing insulin-like growth factor-I (MSCIGF) promote fracture healing and restore new bone formation in Irs1 knockout mice: analyses of MSCIGF autocrine and paracrine regenerative effects. [J] . Granero Molto F, Myers TJ, Weis JA, Stem Cells . 2011,第10期

机译：表达胰岛素样生长因子-I（MSCIGF）的间充质干细胞在Irs1基因敲除小鼠中促进骨折愈合并恢复新的骨形成：MSCIGF自分泌和旁分泌再生作用的分析。
4. In vitro differentiation of mouse embryonic stem cells into pancreatic insulin producing cells using three dimensional alginate scaffolds [C] . Nan Wang, Lee Buttery, Snow Stolnik, Controlled Release Society Annual Meeting and Exposition . 2007

机译：使用三维藻酸盐支架将小鼠胚胎干细胞体外分化为胰腺胰岛素产生细胞
5. Exploring and Potentiating Insulin Resistant Adipose Derived Stem Cells with Insulin Sensitizers [D] . Rawal, Komal Nalinkant. 2020

机译：抗胰岛素抗胰岛素患者的胰岛素抗胰岛素脂肪衍生的干细胞
6. Intravitreal Injection of IGFBP-3 Restores Normal Insulin Signaling in Diabetic Rat Retina [O] . Youde Jiang, Qiuhua Zhang, Jena J. Steinle -1

机译：玻璃体内注射IGFBP-3可恢复糖尿病大鼠视网膜中正常的胰岛素信号
7. Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina. [O] . Youde Jiang, Qiuhua Zhang, Jena J Steinle 2014

机译：玻璃体内注射IGFBp-3可恢复糖尿病大鼠视网膜中的正常胰岛素信号传导。

Stem Cells Make Insulin, Restore Retinas

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