Four-Stranded DNA Makes Human Debut

BREANNA DRAXLER

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Four-Stranded DNA Makes Human Debut

机译：四链DNA使人类首次亮相

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In describing the two-stranded structure of DNA, Cambridge University biologists James Watson and Francis Crick gave us the image of a twisting ladder they called a double helix. The rungs were connected by pairs of chemical bases called nucleotides: Adenine (A) paired with thymine (T), and cytosine (C) with guanine (G). Npw, 60 years later, researchers from the same institution have found a quadruple helix - previously described only in microorganisms - in human cells. In place of rungs, the twisting, four-sided tower has platforms with a guanine nucleo-tide on each of four corners, hence the name G-quadruplex.

机译：在描述DNA的两链结构时，剑桥大学的生物学家詹姆斯·沃森和弗朗西斯·克里克给了我们一个扭曲的梯子的图像，他们称之为双螺旋。梯级通过称为核苷酸的化学碱基对连接：腺嘌呤（A）与胸腺嘧啶（T）配对，胞嘧啶（C）与鸟嘌呤（G）配对。 60年后的Npw，来自同一机构的研究人员在人类细胞中发现了四重螺旋-以前仅在微生物中描述过。代替梯级的是扭曲的四侧塔，在四个角的每个角上都有一个带有鸟嘌呤核苷核苷酸的平台，因此被称为G四联体。

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《Discover》 |2014年第1期|84-84|共1页
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1. The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure [J] . Peter R. Martin, Sophie Couvé, Caroline Zutterling, Scientific reports. . 2017,第1期

机译：人类DNA糖基化酶NEIL1和NEIL3消费品在四链DNA结构中的补骨脂素诱导的DNA-DNA交联。
2. The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure [J] . Peter R. Martin, Sophie Couvé, Caroline Zutterling, Scientific reports. . 2017,第1期

机译：人类DNA糖基化酶NEIL1和NEIL3消费品在四链DNA结构中的补骨脂素诱导的DNA-DNA交联。
3. DNA molecules can drive the assembly of other DNA molecules into specific four-stranded structures. [J] . Marco Haviv-Y, Baran N, Manor H Journal of Molecular Biology . 1999,第1期

机译：DNA分子可以驱动其他DNA分子组装成特定的四链结构。
4. An Integrated Database System for Full-Length Human cDNA in NEDO Full-Length Human cDNA Sequencing Project [C] . Tetsuo Nishikawa, Kouichi Kimura, Tomohiro Yasuda, Workshop on Genome Informatics . 2002

机译：NEDO全长人cDNA测序项目全长人cDNA集成数据库系统
5. The patchy human genome: DNA double-strand breaks in human cells can be repaired by the capture of other DNA fragments. [D] . Little, Kevin C. E. 2005

机译：斑驳的人类基因组：人类细胞中的DNA双链断裂可以通过捕获其他DNA片段来修复。
6. The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure [O] . Peter R. Martin, Sophie Couvé, Caroline Zutterling, -1

机译：人类DNA糖基化酶NEIL1和NEIL3致死补骨脂素诱导的DNA-DNA交联的四链DNA结构中。
7. The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure [O] . Martin, PR, Couve, S, Zutterling, C, 2017

机译：人类DNA糖基化酶NEIL1和NEIL3致死补骨脂素诱导的DNA-DNA交联的四链DNA结构中。

Four-Stranded DNA Makes Human Debut

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