ALL IN THE FOLD

JONATHON KEATS

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ALL IN THE FOLD

机译：全部折叠

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In a sleek biochemistry laboratory at the University of Washington, postdoctoral fellow Yang Hsia is watching yellowish goo - the liquefied remains of E. coli - ooze through what looks like a gob of white marshmallow. "This isn't super exciting," he says. While growing proteins in bacteria and then purifying them, using blobby white resin as a filter, doesn't make for riveting viewing, the end product is extraordinary. Accumulating in Hsia's resin is a totally artificial protein, unlike anything seen in nature, that might just be the ideal chassis for the first universal flu vaccine.

机译：在华盛顿大学一个时尚的生化实验室中，博士后研究员杨霞正在看着微微发粘的黄色粘糊糊（渗出的大肠杆菌液化残留物）渗入看起来像白色的棉花糖小样。他说：“这并不令人兴奋。”在细菌中生长蛋白质然后纯化的过程中，使用粗糙的白色树脂作为过滤器并不能吸引人的目光，但最终产品却非同寻常。与自然界中发现的任何东西不同，在夏亚的树脂中积累的是完全人造的蛋白质，它可能只是第一种通用流感疫苗的理想底盘。

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《Discover》 |2018年第9期|54-62|共9页
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JONATHON KEATS;
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1. Is Protein Folding Rate Dependent on Number of Folding Stages? Modeling of Protein Folding with Ferredoxin-Like Fold [J] . O. V. Galzitskaya Biochemistry . 2010,第6期

机译：蛋白质折叠率取决于折叠阶段数吗？铁氧还蛋白样折叠的蛋白质折叠建模
2. MotifCNN-fold: protein fold recognition based on fold-specific features extracted by motif-based convolutional neural networks [J] . Chen-Chen Li, Bin Liu Briefings in bioinformatics . 2020,第6期

机译：MOTIFCN-FORD：蛋白质折叠识别基于由基于主基的卷积神经网络提取的折叠特异性特征
3. Changing in fold geometry from faulted detachment fold to fault-bend fold, a case study: The Zeloi Anticline in the Dezful Embayment, southwest of Iran [J] . Derikvand Behzad, Alavi Seyed Ahmad, Fard Iraj Abdollahie, Journal of Petroleum Science & Engineering . 2019,第期

机译：从断层脱离折叠到故障弯曲折叠的折叠几何形状，案例研究：伊朗西南部的Dezful Endalling中的Zeloi反对链
4. A 1.5V High Folding Rate Current-Mode Folding Amplifier for Folding and Interpolating ADC [C] . Ro-Min Weng, Chi-Cheng Chao, Institute of Electrical and Electronics EngineersInc. IEEE International Symposium on Circuits and Systems . 2006

机译：用于折叠和内插ADC的1.5V高折叠速率电流模式折叠放大器
5. Syntectonic Fluid Migrations in Foreland Fold-thrust Belts: Evidence from the Wyoming Salient of the Sevier Fold-thrust Belt [D] . Brink-Roby, David. 2019

机译：前陆褶皱带中的透明度液体迁移：来自Sevier折叠带的Wyoming突出的证据
6. Folding of the hammerhead ribozyme: Pyrrolo-cytosine fluorescence separates core folding from global folding and reveals a pH-dependent conformational change [O] . Iwona A. Buskiewicz, John M. Burke 2012

机译：锤头状核酶的折叠：吡咯-胞嘧啶荧光使核心折叠与整体折叠分离并揭示了pH依赖的构象变化
7. Dating folding beyond folding, from layer-parallel shortening to fold tightening, using mesostructures: Lessons from the Apennines, Pyrenees and Rocky Mountains [O] . Olivier Lacombe, Nicolas Beaudoin, Guilhem Hoareau, 2021

机译：使用Mesostructure的层平行缩短来折叠折叠，从层次平行缩短折叠折叠，从赤腹，比利牛斯和落基山脉的课程

ALL IN THE FOLD

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