To evaluate the within-session and inter-session repeatability of a new, short-duration transient visual evoked potential (SD-tVEP) device on normal individuals, we tested 30 normal subjects (20/20 visual acuity, normal 24-2 SITA Standard VF) with SD-tVEP. Ten of these subjects had their tests repeated within 1–2 months from the initial visit. Synchronized single-channel EEG was recorded using a modified Diopsys Enfant™ System (Diopsys, Inc., Pine Brook, New Jersey, USA). A checkerboard stimulus was modulated at two reversals per second. Two different contrasts of checkerboard reversal patterns were used: 85% Michelson contrast with a mean luminance of 66.25 cd/m2 and 10% Michelson contrast with a mean luminance of 112 cd/m2. Each test lasted 20 s. Both eyes, independently and together, were tested 10 times (5 times at each contrast level). The following information was identified from the filtered N75-P100-N135 complex: N75 amplitude, N75 latency, P100 amplitude, P100 latency, and Delta Amplitude (N75-P100). The median values for each eye’s five SD-tVEP parameters were calculated and grouped into two data sets based on contrast level. Mean age was 27.3 ± 5.2 years. For OD only, the median (95% confidence intervals) of Delta Amplitude (N75-P100) amplitudes at 10% and 85% contrast were 4.6 uV (4.1–5.9) and 7.1 uV (5.15–9.31). The median P100 latencies were 115.2 ms (112.0–117.7) and 104.0 ms (99.9–106.0). There was little within-session variability for any of these parameters. Intraclass correlation coefficients ranged between 0.64 and 0.98, and within subject coefficients of variation were 3–5% (P100 latency) and 15–30% (Delta Amplitude (N75-P100) amplitude). Bland–Altman plots showed good agreement between the first and fifth test sessions (85% contrast Delta Amplitude (N75-P100) delta amplitude, mean difference, 0.48 mV, 95% CI, −0.18–1.12; 85% contrast P100 latency delay, −0.82 ms, 95% CI, −3.12–1.46; 10% contrast Delta Amplitude (N75-P100) amplitude, 0.58 mV, 95% CI, −0.27–1.45; 10% contrast P100 latency delay, −2.05 mV, 95% CI, −5.12–1.01). The inter-eye correlation and agreement were significant for both SD-tVEP amplitude and P100 latency measurements. For the subset of eyes in which the inter-session repeatability was tested, the intraclass correlation coefficients ranged between 0.71 and 0.86 with good agreement shown on Bland–Altman plots. Short-duration transient VEP technology showed good within-session, inter-session repeatability, and good inter-eye correlation and agreement.
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机译：为了评估正常个体上新的短时间短暂性视觉诱发电位（SD-tVEP）设备的会话内和会话间可重复性，我们测试了30名正常受试者（20/20视敏度，正常的24-2 SITA标准VF）和SD-tVEP。在初次就诊后的1–2个月内，对其中的10名受试者进行了重复测试。使用改进的Diopsys Enfant™系统（Diopsys，Inc.，美国新泽西州派恩布鲁克），记录了同步单通道EEG。棋盘刺激被调制为每秒两次反转。棋盘反转模式使用两种不同的对比度：85％的迈克尔逊对比度，平均亮度为66.25 cd / m 2 和10％的迈克尔逊对比度，平均亮度为112 cd / m 2 < / sup>。每次测试持续20 s。两只眼睛分别或一起接受10次测试（每个对比水平5次）。从过滤的N75-P100-N135复合物中识别出以下信息：N75振幅，N75潜伏期，P100振幅，P100潜伏期和Delta振幅（N75-P100）。计算出每只眼睛的五个SD-tVEP参数的中值，并根据对比度水平将其分为两个数据集。平均年龄为27.3±5.2岁。仅对于OD，在10％和85％对比度下的Delta振幅（N75-P100）振幅的中值（95％置信区间）为4.6 uV（4.1-5.9）和7.1 uV（5.15-9.31）。 P100延迟的中位数是115.2 ms（112.0–117.7）和104.0 ms（99.9–106.0）。这些参数中的任何一个在会话内的变化都很小。类内相关系数介于0.64和0.98之间，主题变异系数在3％至5％（P100潜伏期）和15％至30％（Δ振幅（N75-P100）振幅）之内。 Bland–Altman图显示了第一和第五次测试之间的良好一致性（85％对比度Delta Amplitude（N75-P100）Delta幅度，均值差，0.48 mV，95％CI，-0.18-1.12； 85％的对比P100延迟， −0.82 ms，95％CI，-3.12-1.46; 10％对比度Delta Amplitude（N75-P100）幅值，0.58 mV，95％CI，-0.27–1.45; 10％对比度P100延迟，-2.05 mV，95％ CI，−5.12-1.01）。眼内相关性和一致性对于SD-tVEP振幅和P100潜伏期测量均很重要。对于测试了会话间可重复性的眼睛子集，类内相关系数的范围在0.71至0.86之间，并且在Bland-Altman图上显示出很好的一致性。短期瞬态VEP技术显示出良好的会话内，会话间可重复性以及良好的眼内关联性和一致性。
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