The Inhibitory Effect of Dinitrosyl Iron Complexes (NO donors) on Myeloperoxidase Activity

Akentieva N. P.; Sanina N. A.; Gizatullin A. R.; Shmatko N. Y.; Goryachev N. S.; Shkondina N. I.; Prikhodchenko T. R.; Aldoshin S. M.

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The Inhibitory Effect of Dinitrosyl Iron Complexes (NO donors) on Myeloperoxidase Activity

机译：二亚硝基铁配合物（NO供体）对髓过氧化物酶活性的抑制作用

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The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated. It was shown that the enzyme MPO is the molecular target of DNICs. It was found that six DNICs inhibited the activity of MPO and one compound potentiated it. The evaluation of their efficiency showed that two DNICs effectively inhibited the activity of MPO by 50% at IC50 = 2 x 10(-4) M and IC50 = 5 x 10(-7) M.

机译：研究了具有功能性含硫配体（NO供体）的二亚硝酰基单核铁配合物（DNIC）的合成类似物对髓过氧化物酶（MPO）活性的影响，并对其效率进行了评估。结果表明，MPO酶是DNIC的分子靶标。发现有六个DNIC抑制了MPO的活性，而一种化合物增强了MPO的活性。对其效率的评估表明，两个DNIC在IC50 = 2 x 10（-4）M和IC50 = 5 x 10（-7）M时能有效抑制MPO活性50％。

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《Doklady biochemistry & biophysics》 |2017年第novaadeca期|389-393|共5页
作者
Akentieva N. P.; Sanina N. A.; Gizatullin A. R.; Shmatko N. Y.; Goryachev N. S.; Shkondina N. I.; Prikhodchenko T. R.; Aldoshin S. M.;
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Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia;

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The Inhibitory Effect of Dinitrosyl Iron Complexes (NO donors) on Myeloperoxidase Activity

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