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首页> 外文期刊>Doklady biochemistry & biophysics >Expression of Components of the Serotonergic System in the Developing Rat Thymus
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Expression of Components of the Serotonergic System in the Developing Rat Thymus

机译:血清素能系统的成分在发育中的大鼠胸腺中的表达

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摘要

The developing thymus of rat fetuses contains all components of the serotonergic system: receptors, enzymes of synthesis, and membrane transporters. The expression of receptors suggests the possibility of a direct influence of serotonin on thymic development. The presence of tryptophan hydroxylase (the key rate-limiting enzyme of serotonin synthesis) and aromatic l-amino acid decarboxylase indicates the ability of fetal thymic cells to synthesize serotonin. It was shown that the cells of a developing thymus can actively uptake extracellular monoamines. The results of this study suggest different functions of the intrathymic and circulating serotonin pools in the regulation of thymic development.
机译:大鼠胎儿发育中的胸腺包含血清素能系统的所有成分:受体,合成酶和膜转运蛋白。受体的表达表明5-羟色胺对胸腺发育有直接影响的可能性。色氨酸羟化酶(5-羟色胺合成的关键限速酶)和芳香族I-氨基酸脱羧酶的存在表明胎儿胸腺细胞合成5-羟色胺的能力。结果表明,发育中的胸腺细胞可以主动摄取细胞外单胺。这项研究的结果表明胸腺内和循环血清素池在胸腺发育调节中的不同功能。

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