Stabilizing Role of Arginine and NO in the Regulation of Voltage-Sensitive L-type Ca~(2+) Current in Cardiocytes

V. V. Dynnik; K. S. Grushin; A. F. Korystova; M. N. Nenov; A. N. Murashov; Yu. M. Kokoz

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Stabilizing Role of Arginine and NO in the Regulation of Voltage-Sensitive L-type Ca~(2+) Current in Cardiocytes

机译：精氨酸和NO在调节心肌细胞电压敏感L型Ca〜（2+）电流中的稳定作用

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Experiments with rat cardiocytes showed that the presence of arginine in isolation and incubation media stabilized the amplitude of basal L-type Ca~(2+) currents and decreased the variability of responses recorded in the presence of regulators of this current. The stabilization of responses is determined by a balanced effect of the secondary messengers cAMP and cGMP on L-type Ca~(2+) channels (L-channels) due to activation in the presence of arginine of cascades of NO- and cGMP-regulated reactions. Under such conditions, the regulation of L-channels by PKG became more pronounced, and the current induced by the activation of β-adrener-gic receptors was compensated with acetylcholine.

机译：用大鼠心肌细胞进行的实验表明，在分离和孵育培养基中存在精氨酸可稳定基础L型Ca〜（2+）电流的振幅，并降低在该电流调节剂存在下记录的响应的变异性。响应的稳定取决于次级信使cAMP和cGMP对L型Ca〜（2+）通道（L通道）的平衡影响，这归因于精氨酸在NO和cGMP调控的级联反应中的激活反应。在这种条件下，PKG对L通道的调节变得更加明显，并且β-肾上腺素能受体的激活所诱导的电流被乙酰胆碱补偿。

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《Doklady biochemistry & biophysics》 |2005年第sepaoct期|p.353-356|共4页
作者
V. V. Dynnik; K. S. Grushin; A. F. Korystova; M. N. Nenov; A. N. Murashov; Yu. M. Kokoz;
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Institute of Theoretical and Experimental Biology, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia;

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正文语种 eng
中图分类分子生物学;
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1. "arginine paradox" in cardiomyocytes of Sprague Dawley and spontaneously hypertensive rats: α_2-adrenoreceptor-mediated regulation of L-type Ca~(2+) currents by L-arginine [J] . Nenov M.N., Berezhnov A.V., Fedotova E.I., Biochemistry (Moscow). Supplement, Series A. Membrane and cell biology . 2010,第4期

机译：Sprague Dawley和自发性高血压大鼠心肌细胞中的“精氨酸悖论”：α_2-肾上腺素受体介导的L-精氨酸对L型Ca〜（2+）电流的调节
2. Polychlorinated Biphenyl-Stimulation of Ca~(2+) Oscillations in Developing Neocortical Cells: A Role for Excitatory Transmitters and L-Type Voltage-Sensitive Ca~(2+) Channels [J] . INGLEFIELD JON R. The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2000,第1aOcta期

机译：多氯联苯刺激发展中的新皮层细胞Ca〜（2+）振荡：兴奋性递质和L型电压敏感Ca〜（2+）通道的作用。
3. Role of Ca(2+)/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca(2+) current during endothelin-1 stimulation. [J] . Komukai K, O Uchi J, Morimoto S, American Journal of Physiology . 2010,第6aPta2期

机译：Ca（2 +）/钙调蛋白依赖性蛋白激酶II在内皮素1刺激过程中心脏L型Ca（2+）电流调节中的作用。
4. Activation of Na~+ and L-type Ca~(2+) Currents in Muscle is More Susceptible to Prolonged High Pressure Treatments than Voltage-dependent Inactivation [C] . O. Friedrich, K.R Kress, H. Ludwig, International Conference on High Pressure Bioscience and Biotechnology . 2003

机译：在肌肉中的Na〜+和L型Ca〜（2+）电流的激活更容易延长高压处理而不是电压依赖性的灭活
5. Regulation of excitation-contraction coupling and L-type Ca(2+) channel activation in skeletal muscle by calmodulin and prolonged depolarization. [D] . O'Connell, Kristen Mary Shannon. 2003

机译：通过钙调蛋白和延长的去极化作用调节骨骼肌中的兴奋收缩偶联和L型Ca（2+）通道的激活。
6. Role of the NO-cGMP pathway in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes [O] . Grégoire Vandecasteele, Thomas Eschenhagen, Rodolphe Fischmeister 1998

机译：NO-cGMP途径在人心房肌细胞L型Ca2 +电流毒蕈碱调节中的作用
7. Reduced density and altered regulation of rat atrial L-type Ca²⁺ current in heart failure [O] . Bond, Richard, Bryant, Simon, Watson, Judy, 2017

机译：心力衰竭大鼠心房L型Ca ^{2 + 电流的密度降低和调节改变}

Stabilizing Role of Arginine and NO in the Regulation of Voltage-Sensitive L-type Ca~(2+) Current in Cardiocytes

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