many other longer-established antidepressant drugs, or how it compares with other therapy for diabetic peripheral neuropathic pain. Therefore, we can see no place for it in either indication. In patients with stress urinary incontinence, pelvic floor exercises are first-line therapy. However, in those with at least 14 episodes of incontinence per week, duloxetine may offer additional benefit where pelvic floor exercises alone arerninsufficiently effective and surgery is unsuitable or undesirable.rnAround a fifth of patients experience nausea when starting duloxetine therapy, causing some to stop taking the treatment. For all indications, when stopping treatment, duloxetine must be withdrawn slowly to reduce the risk of withdrawal symptoms.
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