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The long-run effects of pandemic influenza on the development of children from elite backgrounds: Evidence from industrializing Japan

机译:大流行性流感对具有精英背景的儿童成长的长期影响:来自日本工业化的证据

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This study estimates the lingering effects of fetal exposure to the 1918 influenza pandemic on the development of secondary school and girls' high school students in industrializing Japan. In order to refine the verification of the fetal origins hypothesis, we tried not only to focus on children from elite schools but also to construct the continuous influenza mortality measure using monthly variations in the number of births and influenza deaths. By utilizing a nationwide multidimensional physical examination dataset, we found that fetal exposure to influenza in the pandemic years reduced the heights of boys and girls by approximately 0.3 cm and 0.1 cm, respectively. While the strongest negative magnitude was observed in the pandemic period, the lingering relapses in the post-pandemic period still had considerable adverse effects on height. In relation to the lowest decile group which experienced normal influenza mortality in non-pandemic years, the heights of the boys and girls who experienced pandemic influenza in the womb are approximately 0.6 and 0.3 cm lower. The lingering influenza relapse in the post-pandemic period has an adverse effect on the boys' height, accounting for roughly 80% of the maximum pandemic effect. (C) 2018 Elsevier B.V. All rights reserved.
机译:这项研究估计了1918年流感大流行中胎儿暴露对工业化日本中学生和女高中生发展的持续影响。为了完善对胎儿起源假说的验证,我们不仅尝试着眼于精英学校的孩子,而且还尝试使用出生和流感死亡人数的每月变化构建连续的流感死亡率测度。通过利用全国范围的多维体格检查数据集,我们发现大流行年份的胎儿暴露于流感,使男孩和女孩的身高分别降低了约0.3 cm和0.1 cm。尽管在大流行期间观察到最强的负值,但在大流行后时期的持续复发仍然对身高产生相当大的不利影响。对于在非大流行年中经历了正常流感死亡的最低的十分位数组,在子宫中经历过大流行性流感的男孩和女孩的身高分别低了约0.6和0.3厘米。大流行后时期持续的流感复发对男孩的身高有不利影响,约占最大大流行影响的80%。 (C)2018 Elsevier B.V.保留所有权利。

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