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A higher purpose

机译：更高的目的

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TOWARDS THE end of 2014 a 66-year-old British man named Alistair had a seizure. A scan revealed shocking news. He had an inoperable brain tumour-a glioblastoma-that was likely to kill him in a fewyears. Soon afterwards, he read a newspaper article suggesting that a cocktail of cheap, everyday drugs, chosen for their anti-cancer effects, had helped a patient with the same disease. His doctors were unimpressed but said: "We can't stop you." Four years on Alistair is still taking this drug regimen alongside the "standard-of-care" treatment. The drug cocktail is prescribed by Care Oncology, a private clinic in London, which recommends a statin (a cholesterol-lowering drug), metformin (used to treat type-2 diabetes), doxycycline (an antibiotic) and mebendazole (an anti-worming agent). These may sound radical, but are actually safe, cheap, generic medicines with evidence of some anti-cancer effects. Nonetheless, their labels do not say they treat glioblastoma-nor any other cancer for that matter. This lack of clinical interest is not unusual. There is a huge untapped medicine chest of generic drugs with unexploited uses. Originally approved for one disease, these drugs went off-patent and now show promise in other diseases. Thalidomide, a morning-sickness drug forever linked with scandal and disaster, found new uses in leprosy and a blood cancer. An acne medicine is now part of an effective treatment for a form of leukaemia. Viagra, famously, came from failed work in angina.
机译：快到2014年底，一位名叫Alistair的66岁英国男子癫痫发作。扫描显示了令人震惊的消息。他患有无法手术的脑肿瘤-胶质母细胞瘤-可能在几年内杀死他。此后不久，他阅读了一篇报纸文章，暗示一种廉价的日常药物混合物（因其具有抗癌作用而被选中）对患有相同疾病的患者有所帮助。他的医生不为所动，但说：“我们无法阻止您。”在阿利斯泰尔（Alistair）上接受治疗的四年仍然与“标准护理”疗法一起服用。伦敦一家私人诊所的Care Oncology开出了这种药物鸡尾酒，建议使用他汀类药物（降胆固醇药物），二甲双胍（用于治疗2型糖尿病），强力霉素（一种抗生素）和甲苯达唑（一种抗蠕虫药）代理）。这些听起来可能很激进，但实际上是安全，便宜的非专利药，具有某些抗癌作用的证据。尽管如此，他们的标签并没有说他们在治疗胶质母细胞瘤，也没有治疗其他任何癌症。缺乏临床兴趣并不罕见。有大量未经开发的未开发用途的仿制药。这些药物最初被批准用于一种疾病，但已失去专利保护，现在在其他疾病中显示出希望。 Thalidomide是一种永远与丑闻和灾难联系在一起的晨吐药，在麻风病和血液癌中发​​现了新用途。痤疮药物现已成为治疗白血病的有效方法的一部分。著名的伟哥来自心绞痛的失败工作。

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    《The economist》 |2019年第9132期|51-52|共2页
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