The topography of tumours

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The topography of tumours

机译：肿瘤的地形

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PERHAPS MORE than any other, cancer is seen as a disease of genes gone wrong. So, as genetic-sequencing technology has become cheaper and faster, cancer scientists are using it to check which changes to genes cause tumours to spread. The latest insights from one group, the international Pan-Cancer Analysis of Whole Genomes (PCAWG), are revealed this week in Nature. In an analysis of the full genomes of 2,658 samples of 38 types of tumour taken from the bladder to the brain, the researchers give a blow-by-blow account of how a series of genetic mutations can turn normal cells into runaway clones. It provides the most comprehensive analysis yet of where to find this damaging disruption to DNA and, by unpicking the genetics of what makes cancer tick, just how hard it will be to tame.

机译：相比任何其他疾病，癌症被认为是一种基因错误的疾病。因此，随着基因测序技术变得越来越便宜和越来越快，癌症科学家正在使用它来检查哪些基因变化会导致肿瘤扩散。本周在《自然》杂志上披露了来自一个小组的最新见解，即国际全基因组泛癌分析（PCAWG）。在对从膀胱到大脑的38种肿瘤的2658个样本的全基因组进行分析后，研究人员对一系列基因突变如何将正常细胞转变为失控的克隆作了详尽的说明。它提供了迄今为止最全面的分析，可以从何处找到这种破坏性的DNA破坏，并通过剔除造成癌症的原因的遗传基因，驯服将有多困难。

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《The economist》 |2020年第9180期|66-67|共2页
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1. Topographies of ‘care pathways’ and ‘healthscapes’: reconsidering the multiple journeys of people with a brain tumour [J] . Llewellyn Henry, Higgs Paul, Sampson Elizabeth L, Sociology of health & illness . 2018,第3期

机译：“护理途径”和“健康展”的地形：重新考虑脑肿瘤的人的多重旅程
2. Differential kinetic features by tumour topography in cutaneous small-cell neuroendocrine (Merkel cell) carcinomas. [J] . Pozo L, Sanchez-Carrillo J, Martinez A, Journal of the European Academy of Dermatology and Venereology: JEADV . 2007,第9期

机译：皮肤小细胞神经内分泌（Merkel细胞）癌中肿瘤的地形动力学差异动力学特征。
3. Topography-modified refraction: adjustment of treated cylinder amount and axis to the topography versus standard clinical refraction in myopic topography-guided LASIK [J] . Clinical ophthalmology . 2017,第3期

机译：地形修改后的屈光度：在近视地形指导的LASIK中调整已处理圆柱体的量和轴的形貌与标准临床屈光的关系
4. Metabolic characterization of tumour-tumour microenvironment interactions in human colorectal cancer using MALDI mass spectrometry imaging [C] . Henry Shion, Panagiotis A. Vorkas, Reza Mirnezami, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：使用MALDI质谱成像的人结直肠癌肿瘤微环境相互作用的代谢特征
5. The dynamic tumour microenvironment: From tumour perfusion to differential gene expression. [D] . Bennewith, Kevin Leslie. 2005

机译：动态肿瘤微环境：从肿瘤灌注到差异基因表达。
6. Sequence topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus. [O] . R Moore, G Casey, S Brookes, 1986

机译：小鼠int-2的序列形貌和蛋白质编码潜力：被小鼠乳腺肿瘤病毒激活的推定致癌基因。
7. Topographies of ‘care pathways’ and ‘healthscapes’: reconsidering the multiple journeys of people with a brain tumour [O] . Henry Llewellyn, Paul Higgs, Elizabeth L Sampson, 2017

机译：“护理途径”和“健康展”的地形：重新考虑脑肿瘤的人的多次旅程

The topography of tumours

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