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The quest for the protein chip

机译:对蛋白质芯片的追求

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A picture may be worth a thousand words. But a gene is worth thousands of proteins that paint a rich picture of human biology. For biologists entering the burgeoning field of proteomics, that is proving a blessing and a curse. Studying proteins has long been a slow, arduous process. In the first place, more than 3m proteins make up the human proteome, compared with about 40,000 genes in the genome. And unlike strands of DNA, proteins are three-dimensional units whose orientation and folding play an important role in their function. Equally vexing for researchers, proteins tend to be fragile and prone to denaturing while being studied.
机译:图片可能值一千个字。但是一个基因价值数千种蛋白质,可以描绘出人类生物学的丰富图画。对于进入新兴的蛋白质组学领域的生物学家来说,这是一种祝福和诅咒。长期以来,研究蛋白质是一个缓慢而艰巨的过程。首先,人类蛋白质组中有超过3m种蛋白质,而基因组中约有40,000个基因。与DNA链不同,蛋白质是三维单元,其方向和折叠在其功能中起着重要作用。对于研究人员而言,同样令人烦恼的是,蛋白质在研究过程中往往易碎且易于变性。

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