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首页> 外文期刊>Ecotoxicology and Environmental Safety >Long-term exposures to Hypersaline particles associated with increased levels of Homocysteine and white blood cells: A case study among the village inhabitants around the semi-dried Lake Urmia
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Long-term exposures to Hypersaline particles associated with increased levels of Homocysteine and white blood cells: A case study among the village inhabitants around the semi-dried Lake Urmia

机译：长期暴露于与同型半胱氨酸和白细胞水平升高有关的高盐颗粒：以半干燥的乌尔米亚湖附近的乡村居民为例

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摘要

The dried bed of the world's second largest permanent Hypersaline lake, Lake Urmia, acts as a Hypersaline particle emission source. In the present study we aim to assess the health impact of this disaster and examine the association of Hypersaline particles with total and differential white blood cell counts (WBC) and homocysteine (Hcy), the biomarkers of cardiovascular diseases, in the residents around Lake Urmia. Based on the previous study three regions were selected as clean and polluted regions for ambient particulate matter (APM) from 2008 to 2015. Concentration of APM (PM10, PM2.5 and PM1; particulate matter with aerodynamic diameter of less than 10, 2.5 and 1 mu m, respectively) was measured in the selected regions and totally, 123 participants were selected randomly from villagers who have lived in the selected regions for at least eight years. Biomarkers and covariates were measured in the selected regions and were analyzed using multiple linear regression models. We found a statistically significant association between APM and selected biomarkers (Hcy, total WBC, neutrophil, monocyte, lymphocyte and basophile) in the polluted regions. These results are consistent with our hypothesis that long-term exposure to Hypersaline particles originated from drying Urmia Hypersaline Lake is related to increased cardiovascular risk biomarkers.
机译：世界第二大永久性超盐湖（乌尔米亚湖）的干燥床是超盐颗粒的排放源。在本研究中，我们旨在评估这场灾难对健康的影响，并检查Urmia湖附近居民中超盐颗粒与总和差异白细胞计数（WBC）和高半胱氨酸（Hcy）（心血管疾病的生物标志物）的关联。根据之前的研究，从2008年到2015年，选择了三个区域作为清洁和污染区域的环境颗粒物（APM）。APM的浓度（PM10，PM2.5和PM1；空气动力学直径小于10、2.5和10的颗粒物）在所选区域中分别测量了1微米），总共从居住在所选区域中至少八年的村民中随机选择了123名参与者。在选定区域中测量生物标志物和协变量，并使用多个线性回归模型进行分析。我们在受污染的地区发现APM与选定的生物标志物（Hcy，总WBC，中性粒细胞，单核细胞，淋巴细胞和嗜碱细胞）之间存在统计学上的显着关联。这些结果与我们的假设一致，即长期暴露于干燥的Urmia Hypersaline Lake引起的Hypersaline颗粒与心血管风险生物标志物增加有关。

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  • 来源
    《Ecotoxicology and Environmental Safety》 |2019年第3期|631-639|共9页
  • 作者

    Samadi Mohammad Taghi; Khorsandi Hassan; Asl Farshad Bahrami; Poorolajal Jalal; Tayebinia Heidar;

  • 作者单位

    Hamadan Univ Med Sci, Sch Publ Hlth, Res Ctr Hlth Sci, Hamadan, Iran|Hamadan Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth Engn, Hamadan, Iran;

    Urmia Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth Engn, Orumiyeh, Iran;

    Hamadan Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth Engn, Hamadan, Iran;

    Hamadan Univ Med Sci, Sch Publ Hlth, Res Ctr Hlth Sci, Hamadan, Iran|Hamadan Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Hamadan, Iran;

    Hamadan Univ Med Sci, Sch Med, Dept Clin Biochem, Hamadan, Iran;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Air pollution; Biomarker; Cardiovascular diseases; Lake Urmia; PM;

    机译：空气污染;生物标志物;心血管疾病;尿毒症;下午;

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