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首页> 外文期刊>Endocrine journal >Melatonin as a free radical scavenger in the ovarian follicle
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Melatonin as a free radical scavenger in the ovarian follicle

机译：褪黑激素作为卵巢卵泡中的自由基清除剂

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摘要

This review summarizes new findings related to beneficial effects of melatonin (N-acetyl-5-methoxytryptamine) on reproductive physiology. Recently many researchers have begun to study the local role of melatonin as an antioxidant. We focused on intra-follicular role of melatonin in the ovary. Melatonin, secreted by the pineal gland, is taken up into the follicular fluid from the blood. Reactive oxygen species (ROS) are produced within the follicles, during the ovulatory process. Melatonin reduces oxidative stress as an antioxidant, and contribute to oocyte maturation, embryo development and luteinization of granulosa cells. Our clinical study demonstrated that melatonin treatment for infertile women increases intra-follicular melatonin concentrations, reduces intra-follicular oxidative damage, and elevates fertilization and pregnancy rates. Melatonin treatment also improves progesterone production by corpus luteum in infertile women with luteal phase defect. Melatonin treatment could become a new cure for improving oocyte quality and luteal function in infertile women.
机译：这篇综述总结了与褪黑激素（N-乙酰基-5-甲氧基色胺）对生殖生理的有益作用有关的新发现。最近，许多研究人员已开始研究褪黑激素作为抗氧化剂的局部作用。我们专注于褪黑激素在卵巢中的卵泡内作用。松果体分泌的褪黑激素从血液中吸收到卵泡液中。在排卵过程中，卵泡内会产生活性氧（ROS）。褪黑素可作为抗氧化剂降低氧化应激，并有助于卵母细胞成熟，胚胎发育和粒细胞黄体化。我们的临床研究表明，不育妇女的褪黑激素治疗可增加卵泡内褪黑素的浓度，减少卵泡内的氧化损伤，并提高受精率和妊娠率。褪黑激素治疗还可以改善黄体期缺陷的不育女性的黄体生成黄体素的能力。褪黑素治疗可能成为改善不育女性卵母细胞质量和黄体功能的新疗法。

著录项

  • 来源
    《Endocrine journal》 |2013年第1期|1-13|共13页
  • 作者

    Hiroshi Tamura; Akihisa Takasaki; Toshiaki Taketani; Manabu Tanabe; Fumie Kizuka; Lifa Lee; Isao Tamura; Ryo Maekawa; Hiromi Asada; Yoshiaki Yamagata; Norihiro Sugino;

  • 作者单位

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Minamikogushi 1-1-1, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Saiseikai Shimonoseki General Hospital, Shimonoseki 759-6603, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

    Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    melatonin; ovarian follicle; reactive oxygen species; oocyte; granulosa cell;

    机译：褪黑激素卵巢卵泡活性氧卵母细胞颗粒细胞;

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