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首页> 外文期刊>Endocrine journal >Low-molecular-weight adiponectin is more closely associated with episodes of asthma than high-molecular- weight adiponectin
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Low-molecular-weight adiponectin is more closely associated with episodes of asthma than high-molecular- weight adiponectin

机译：与高分子量脂联素相比，低分子量脂联素与哮喘发作的相关性更高

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摘要

Adiponectin is divided into high-molecular-weight (HMW), middle-molecular-weight (MMW) and low-molecular-weight (LMW) types. While HMW adiponectin has been studied by many researchers, the roles of MMW and LMW adiponectin have not yet been sufficiently elucidated. In addition, there are conflicting findings regarding the role of adiponectin in chronic inflammatory diseases, especially asthma. Therefore, we compared patients who suffered episodes of asthma in the past (=asthmatics) with those who did not (=non-asthmatics) in order to investigate the relationship between asthma and HMW, MMW and LMW adiponectin. The subjects in this study included 76 university students. None of the subjects were smokers, on regular medications or seeing a doctor regularly at the time. Fourteen subjects reported past histories of asthma. We also measured and compared the levels of leptin and ghrelin to that of adiponectin, as these hormones are connected with inflammatory conditions. Although the physical data of the asthmatics were similar to those of the non-asthmatics, the levels of ghrelin and all fractions of adiponectin tended to be lower in the asthmatics than in the non-asthmatics. While the levels of MMW and LMW adiponectin in the asthmatics were found to be significantly low, the levels of ghrelin and HMW adiponectin were not clear. According to a multivariate regression analysis of the MMW and LMW adiponectin levels, asthma was found to be more significantly associated with the LMW adiponectin level than age, waist circumference or HDL-C. The results suggest that LMW adiponectin may be associated with episodes of asthma in males.
机译：脂联素分为高分子量（HMW），中分子量（MMW）和低分子量（LMW）类型。尽管许多研究人员已经研究了HMW脂联素，但尚未充分阐明MMW和LMW脂联素的作用。另外，关于脂连蛋白在慢性炎性疾病，特别是哮喘中的作用也有矛盾的发现。因此，为了研究哮喘与HMW，MMW和LMW脂联素之间的关系，我们将过去经历过哮喘发作（=哮喘）和未经历哮喘（=非哮喘）的患者进行了比较。本研究的对象包括76名大学生。受试者中没有一个是吸烟者，没有服用过常规药物，也没有定期去看医生。 14名受试者报告了过去的哮喘病史。我们还测量并比较了瘦素和生长素释放肽与脂联素的水平，因为这些激素与炎症有关。尽管哮喘患者的身体数据与非哮喘患者相似，但与非哮喘患者相比，ghrelin和脂联素所有组分的水平往往较低。虽然发现哮喘患者中MMW和LMW脂联素的水平非常低，但生长素释放肽和HMW脂联素的水平尚不清楚。根据MMW和LMW脂联素水平的多元回归分析，发现哮喘与LMW脂联素水平显着相关，而不是年龄，腰围或HDL-C。结果表明，LMW脂联素可能与男性哮喘发作有关。

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  • 来源
    《Endocrine journal》 |2013年第1期|119-125|共7页
  • 作者

    Yuuki Matsumoto; Kouji Toyomasu; Naohisa Uchimura; Tatsuya Ishitake;

  • 作者单位

    Department of Environmental Medicine, Kurume University School of Medicine, 67 Asahi town, Kurume city, Fukuoka prefecture, 830-0011, Japan;

    Institute of Health and Sports Science, Kurume University, Kurume 839-0851, Japan;

    Department of Neuropsychiatry, Kurume University School of Medicine, Kurume 830-0011, Japan;

    Department of Environmental Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    asthma; LMW adiponectin; MMW adiponectin; ghrelin; male;

    机译：哮喘;LMW脂联素;MMW脂联素;ghrelin;男;

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