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首页> 外文期刊>Endocrine journal >Usefulness of HbA1c to diagnose diabetes among Japanese children detected by a urine glucose screening program in the Tokyo Metropolitan Area
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Usefulness of HbA1c to diagnose diabetes among Japanese children detected by a urine glucose screening program in the Tokyo Metropolitan Area

机译：HbA1c在东京都会区尿糖筛查程序中发现的日本儿童中诊断糖尿病的有用性

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摘要

We examined the correlation between plasma glucose (PG) and hemoglobin Ale (HbAlc) to evaluate the usefulness and limitations of applying the new diagnostic criteria for diabetes to Japanese pediatric patients. Data were collected from 298 school children who took an oral glucose tolerance test (OGTT) at a school-based urinary glucose screening program in the Tokyo Metropolitan Area between 1988 and 2009. Mean (SD) age of the children was 11.9 (2.5) years. Male-to-female ratio was 1:1.1. Children were diagnosed with renal glucosuria (n= 146), diabetes mellitus (n=133), or the Japan Diabetes Society (JDS) "borderline type" (n=l 9). Median (range) values of fasting plasma glucose (FPG), 2-h plasma glucose in an OGTT (OGTT-2h), and HbAlc were 101 (76-378) mg/dL, 146.5 (57-563) mg/dL, and 6.05 (4.7-14.1) %. The correlation between PG and HbAlc was analyzed using least squares regression, and HbAlc was found to highly correlate with PG. From estimated regression equations, mean values of FPG and OGTT-2h corresponding to an HbAlc of 6.5% were calculated to be 111.4 mg/dL and 170.4 mg/dL. The mean values of HbA 1 c corresponding to an FPG of 126 mg/dL and OGTT-2h of 200 mg/dL were calculated to be 7.5% and 7.8%. The mean values of PG corresponding to HbAlc of 6.5% were lower than found in adults as analyzed by JDS. The mean values of HbAlc corresponding to diabetic type PG were higher than found in adults.
机译：我们检查了血浆葡萄糖（PG）和血红蛋白Ale（HbAlc）之间的相关性，以评估将新的糖尿病诊断标准应用于日本儿科患者的有用性和局限性。数据收集自1988年至2009年之间在东京都会区一项基于学校的尿葡萄糖筛查计划的口服葡萄糖耐量测试（OGTT）的298名在校儿童。儿童的平均（SD）年龄为11.9（2.5）岁。男女比例为1：1.1。儿童被诊断患有肾性糖尿症（n = 146），糖尿病（n = 133）或日本糖尿病学会（JDS）的“边界型”（n = 1 19）。空腹血糖（FPG），OGTT（OGTT-2h）和HbAlc中2小时血浆葡萄糖的中位（范围）值为101（76-378）mg / dL，146.5（57-563）mg / dL，和6.05（4.7-14.1）％。使用最小二乘回归分析了PG和HbAlc之间的相关性，发现HbAlc与PG高度相关。根据估计的回归方程式，对应于HbAlc为6.5％的FPG和OGTT-2h的平均值分别为111.4 mg / dL和170.4 mg / dL。计算出的Fb为126 mg / dL和OGTT-2h为200 mg / dL的HbA 1c的平均值分别为7.5％和7.8％。通过JDS分析，与HbAlc相对应的PG平均值为6.5％，低于成年人。糖尿病型PG对应的HbAlc平均值高于成人。

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  • 来源
    《Endocrine journal》 |2012年第6期|p.465-471|共7页
  • 作者

    Erika Ogawa; Tatsuhiko Urakami; Junichi Suzuki; Ayako Yoshida; Shori Takahashi; Hideo Mugishima;

  • 作者单位

    Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan;

    Department of Pediatrics and Child Health, Nihon University School of Medicine,1-8-13 Kanda-surugadai, Chiyoda-ku, Tokyo 101-8309, Japan;

    Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan;

    Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan;

    Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan;

    Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    hemoglobin ale (HbAlc); plasma glucose; oral glucose tolerance test (OGTT); diagnostic criteria; correlation;

    机译：血红蛋白啤酒（HbAlc）;血浆葡萄糖口服葡萄糖耐量测试（OGTT）;诊断标准;相关性;

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