Effect of pH on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli

Victor Lorian; L. D. Sabath

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Effect of pH on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli

机译：pH对500分离株红霉素活性的影响

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Erythromycin was found to be a more effective inhibitor of gram-negative bacilli in alkaline medium than in neutral or acid medium. A definite effect was noted with all of 500 recent clinical isolates of Escherichia coli, Klebsiella-Enterobacter, Pseudomonas aeruginosa, and Proteus mirabilis studied, but it was most striking with E. coli. At pH 8.5 all strains, except for 14% of those of P. mirabilis, were inhibited by concentrations of erythromycin readily achieved in urine with common therapeutic doses.

机译：发现红霉素是碱性培养基中克革兰阴性杆菌的更有效抑制剂，而不是中性或酸介质。所有500个最近的大肠杆菌临床分离株，Klebsiella-eanterobacter，假单胞菌铜绿假单胞菌和蛋白质米拉米斯的临床分离株所有效果都已注意到，但它与大肠杆菌最引人注目。在pH8.5的所有菌株中，除了在尿液中含有常见治疗剂量的尿液中易于实现的红霉素的浓度抑制了14毫拉米。

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《Applied Microbiology》 |1970年第5期|共3页
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Victor Lorian; L. D. Sabath;
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1. Effect of pH on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli [J] . Victor Lorian, L. D. Sabath Applied Microbiology . 1970,第5期

机译：pH对500分离株红霉素活性的影响
2. Effect of pH on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli [J] . Victor Lorian, L. D. Sabath Applied Microbiology . 1970,第5期

机译：pH对500分离株红霉素活性的影响
3. Performance Evaluation of the Newly Developed BD Phoenix NMIC-500 Panel Using Clinical Isolates of Gram-Negative Bacilli [J] . Byeol Yi Park M.T, Demiana Mourad, Jun Sung Hong, Annals of laboratory medicine. . 2019,第5期

机译：使用革兰氏阴性杆菌临床分离株对新开发的BD Phoenix NMIC-500面板进行性能评估
4. Specificity determinants dramatically reduce hemolytic activity in amphipathic α-helical antimicrobial peptides: antimicrobial activity against Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa [C] . Ziqing Jiang, Adriana I. Vasil, Lajos Gera, International Conference on Antimicrobial Research . 2011

机译：特异性决定簇显着降低两亲性α-螺旋抗微生物肽中的溶血活性：针对革兰氏阴性病原体的抗菌活性，肺杆菌和假单胞菌铜绿假单胞菌
5. PARTICIPATION OF IMMUNOGLOBULIN AND THE CLASSICAL AND ALTERNATIVE COMPLEMENT PATHWAYS IN OPSONOPHAGOCYTOSIS AND INTRACELLULAR KILLING OF GRAM-NEGATIVE BACILLI [D] . WELSH, PHYLLIS LEIST. 1981

机译：免疫球蛋白的参与以及革兰氏阴性杆菌的吞噬和细胞内杀伤的经典和替代性补充途径
6. Effect of pH on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli [O] . Victor Lorian, L. D. Sabath 1970

机译：pH值对500株革兰氏阴性杆菌红霉素活性的影响
7. Effect of p H on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli [O] . Victor Lorian, L. D. Sabath 1970

机译：P H对500分离株革兰阴性杆菌的红霉素活性的影响

Effect of pH on the Activity of Erythromycin Against 500 Isolates of Gram-Negative Bacilli

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