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首页> 外文期刊>Infection and immunity >Effects of BCG, Corynebacterium parvum, and methanol-extration residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice.
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Effects of BCG, Corynebacterium parvum, and methanol-extration residue in the reduction of mortality from Staphylococcus aureus and Candida albicans infections in immunosuppressed mice.

机译：BCG，棒状杆菌和甲醇提取残余物的影响在免疫抑制小鼠中葡萄球菌和念珠菌念珠菌感染降低死亡率。

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摘要

An immunosuppressed mouse model was devised to test the effects of immunopotentiators on the prevention of bacterial and fungal infections. The effects of BCG and Corynebacterium were tested against Staphylococcus aureus and Candida albicans infection. The effect of methanol-extraction residue (MER-BCG) was tested against S. aureus septicemia. CDF mice were given various doses of BCG, 1.0 mg of C. parvum, or 0.5 mg of MER intraperitoneally at varying intervals before injection of an intravenous bacterial challenge. Four days before challenge, 300 mg of cyclophosphamide per ml was given intraperitoneally. BCG (106 colony-forming units) reduced mortality due to S.aureus at pretreatment intervals of 3, 7, 14, and 28 days. Isonicotinic acid hydrazide treatment elimated the protective effect of the live BCG. C. parvum was as effective as BCG against S. aureus septicemia when given 3 days before infection, but lost most of its protective effect after that time. MER protected at doses as small as 0.25 mg when given 25 days prior to challenge. Both BCG and C. parvum exerted a protective effect against Candida albicans infection.
机译：设计了一种免疫抑制的小鼠模型，以测试免疫监测剂对预防细菌和真菌感染的影响。测试BCG和棒状杆菌的效果对金黄色葡萄球菌和念珠菌的念珠菌感染。甲醇提取残基（MER-BCG）对S.UUREUS败血症的影响。在注射静脉注射细菌攻击之前，将CDF小鼠赋予各种剂量的BCG，1.0mg C.Parvum，或0.5mg以不同的间隔腹膜内的MER。挑战前四天，每mL 300mg环磷酰胺被腹膜内给出。 BCG（106个菌落成型单位）由于S.aureus在预处理间隔为3,7,14和28天而降低死亡率。异烟酸酰肼处理消除了活性BCG的保护作用。 C. Parvum在感染前3天给予3天时，PARVUM与S.UUREUS败血症的BCG有效，但在那段时间后损失了大部分的保护作用。 MER在挑战前25天时以小于0.25毫克的剂量保护。 BCG和C.Parvum均对念珠菌醛糖类感染的保护作用。

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