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首页> 外文期刊>British Journal of Cancer >Stimulation of B-lymphocyte colony formation in vitro by sera from patients with leukaemia or lymphoma|[ast]|
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Stimulation of B-lymphocyte colony formation in vitro by sera from patients with leukaemia or lymphoma|[ast]|

机译：从白血病或淋巴瘤患者血清刺激体外B淋巴细胞菌落形成[AST] |

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摘要

Studies were made on the effects of 665 sera, from normal donors or patients with various diseases, on B-lymphocyte colony formation in agar by mouse spleen cells. Undiluted serum from most normal donors inhibited colony formation, but 43-53% of sera from patients with histiocytic lymphoma, lymphocytic lymphoma or Hodgkin's disease stimulated colony formation, serum activity correlating with the stage of the disease. Moderate colony-stimulating activity was observed with serum taken from patients with acute lymphoid or myeloid leukaemia following, but not prior to, chemotherapy. Colony stimulating activity was not correlated with the blood group of serum donors and could not be ascribed to the presence of endotoxin, red cells or mouse red cell haemagglutinins in the active sera. Elevated colony stimulating activity was not observed in sera from patients with non-neoplastic disorders ot haemopoiesis or with diseases of other organ systems.
机译：通过小鼠脾细胞对琼脂的B淋巴细胞菌落形成，从正常供体或各种疾病的患者的疗效作用于665例血清的影响。来自大多数正常供体的未稀释的血清抑制菌落形成，但来自组织细胞淋巴瘤患者的43-53％的血清，淋巴细胞淋巴瘤或霍奇金病刺激菌落形成，血清活性与疾病的阶段相关。观察到中度菌落刺激活性，血清患有急性淋巴或髓性白血病的患者，但在化疗之前没有。菌落刺激活性与血清供体的血液组没有相关，并且不能归因于活性血清中的内毒素，红细胞或小鼠红细胞血凝素存在。从非肿瘤障碍患者患有血液造血或其他器官系统的疾病，在血清中未观察到殖民地刺激活性。

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