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首页> 外文期刊>Infection and immunity >Intestinal and serum antibody responses in mice after oral immunization with Salmonella, Escherichia coli, and Salmonella-Escherichia coli hybrid strains.
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Intestinal and serum antibody responses in mice after oral immunization with Salmonella, Escherichia coli, and Salmonella-Escherichia coli hybrid strains.

机译：用沙门氏菌，大肠杆菌和沙门氏菌和沙门氏菌的大肠杆菌杂交菌株口服免疫后小鼠肠道和血清抗体反应。

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摘要

After oral feeding of mice with avirulent Salmonella, Escherichia coli, or hybrid strains, only certain bacterial strains were able to multiply and persist within the small intestinal Peyer's patches. After oral vaccination alone, or oral priming and subsequent parenteral boosting, antibody class and titers were detected, using a radioimmunoassay on serum and intestinal fluid or a plaque-forming cell assay on spleens. Only those strains that persisted in the Peyer's patches stimulated the production of serum and intestinal immunoglobulin A antibodies against their respective O antigens. Nonpersistent strains were weakly immunogenic, and antibodies, when present, were largely non-immunoglobulin A and confined to the serum.
机译：在用无毒沙门氏菌，大肠杆菌或杂交菌株口腔喂食小鼠后，只有某些细菌菌株能够在小肠Peyer的贴片内繁殖并持续存在。单独口腔接种疫苗接种后，使用放射免疫测定在血清和肠液上的放射性杂种或在脾脏上进行口腔灌注和随后的肠胃外升压，或在脾脏上的斑块形成细胞测定。只有那些坚持在Peyer的补丁中的菌株刺激了血清和肠免疫球蛋白的产生抗体的抗体。非运动菌株是弱免疫原性的，并且存在时，抗体在很大程度上是非免疫球蛋白A并限制在血清上。

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