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首页> 外文期刊>Inside EPA's environmental policy alert >Advisors' Draft Review Urges EPA To Reconsider Novel Skin Cancer Risk
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Advisors' Draft Review Urges EPA To Reconsider Novel Skin Cancer Risk

机译：顾问的草案审查敦促EPA重新考虑新型皮肤癌风险

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摘要

The first draft report from the panel of science advisors peer reviewing EPA's draft assessment of the human health risks of the petroleum chemical benzo(a)pyrene (BaP) generally concurs with many of the agency's conclusions about the hazards the chemical poses, but is critical of most of the risk estimates EPA has calculated, particularly a novel skin cancer risk estimate. The panel's draft report agrees with EPA's September 2014 draft Integrated Risk Information System (IRIS) assessment of BaP that the chemical is a developmental neurotoxicant, a reproductive toxicant, presents hazards to the human immune system and concurs with EPA's proposed classification of BaP as a human carcinogen. The panel also concurs with two conclusions that tighten EPA's cancer risk estimates: that BaP causes cancer through a mutagenic mode of action, or biological pathway, and as a result, that EPA should use an additional safety factor intended to protect children from mutagenic agents in its BaP cancer risk calculations.
机译：科学顾问小组同行审查EPA对石油化学苯并（a）re（BaP）的人类健康风险的评估草案的第一份报告初稿总体上同意了该机构的许多结论，认为该化学物质具有危害，但至关重要。 EPA计算出的大多数风险估计中，特别是新的皮肤癌风险估计。专家组的报告草稿与EPA 2014年9月对BaP的综合风险信息系统（IRIS）评估草案相一致，该化学品是一种发育中的神经毒物，生殖毒物，对人体免疫系统构成危害，并同意EPA提议的将BaP归类为人类。致癌物。专家组还同意两个结论，这些结论使EPA的癌症风险估算更加严格：BaP通过诱变作用模式或生物途径引起癌症，因此EPA应该使用额外的安全系数来保护儿童免受致突变剂的侵害。 BaP癌症风险计算。

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