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首页> 外文期刊>Environment international >Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study
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Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study

机译：CHAMACOS研究中，产前母亲个人护理产品化学生物标志物的尿液浓度与儿童呼吸道和过敏性结局之间的关联

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Background: Personal care product chemicals may be contributing to risk for asthma and other atopic illnesses. The existing literature is conflicting, and many studies do not control for multiple chemical exposures.Methods: We quantified concentrations of three phthalate metabolites, three parabens, and four other phenols in urine collected twice during pregnancy from 392 women. We measured T helper 1 (Th1) and T helper 2 (Th2) cells in their children's blood at ages two, five, and seven, and assessed probable asthma, aeroallergies, eczema, and lung function at age seven. We conducted linear and logistic regressions, controlling for additional biomarkers measured in this population as selected by Bayesian Model Averaging.Results: The majority of comparisons showed null associations. Mono-n-butyl phthalate (MnBP) was associated with higher Th2% (RR: 10.40, 95% CI: 3.37, 17.92), and methyl paraben was associated with lower Th1% (RR: -3.35, 95% CI: -6.58, -0.02) and Th2% at borderline significance (RR: -4.45, 95% CI: -8.77, 0.08). Monoethyl phthalate was associated with lower forced expiratory flow from 25 to 75% of forced vital capacity (FEF25-75%) (RR: -3.22 L/s, 95% CI: -6.02, -0.34). Propyl paraben (OR: 0.86, 95% CI: 0.74, 0.99) was associated with decreased odds of probable asthma.Conclusions: While some biomarkers, particularly those from low molecular weight phthalates, were associated with an atopic cytokine profile and poorer lung function, no biomarkers were associated with a corresponding increase in atopic disease.
机译：背景：个人护理产品中的化学物质可能会导致哮喘和其他特应性疾病的风险。现有文献相互矛盾，许多研究并未控制多次化学暴露。方法：我们对从392名妇女怀孕期间两次收集的尿液中的三种邻苯二甲酸酯代谢物，三种对羟基苯甲酸酯和四种其他酚的浓度进行了定量。我们在二，五和七岁时测量了孩子血液中的T辅助1（Th1）和T辅助2（Th2）细胞，并评估了七岁时可能的哮喘，气敏，湿疹和肺功能。我们进行了线性和逻辑回归，控制了根据贝叶斯模型平均法在该人群中测得的其他生物标志物。结果：大多数比较显示无关联。邻苯二甲酸单正丁酯（MnBP）与较高的Th2％相关（RR：10.40，95％CI：3.37，17.92），而对羟基苯甲酸甲酯与较低的Th1％相关（RR：-3.35，95％CI：-6.58 （-0.02）和临界值显着水平的Th2％（RR：-4.45，95％CI：-8.77，0.08）。邻苯二甲酸单乙酯与较低的强制呼气流量相关，后者从强制肺活量的25％降至75％（FEF25-75％）（RR：-3.22 L / s，95％CI：-6.02，-0.34）。对羟基苯甲酸丙酯（OR：0.86，95％CI：0.74，0.99）与可能患哮喘的几率降低有关。结论：虽然某些生物标志物，特别是来自低分子量邻苯二甲酸酯的生物标志物与特应性细胞因子谱和肺功能较弱有关，没有生物标志物与特应性疾病的相应增加相关。

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