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Probabilistic approach for assessing infants' health risks due to ingestion of nanoscale silver released from consumer products

机译：摄入从消费品中释放的纳米级银引起的婴儿健康风险评估的概率方法

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摘要

Silver nanoparticles (n-Ag) are widely used in consumer products and many medical applications because of their unique antibacterial properties. Their use is raising concern about potential human exposures and health effects. Therefore, it is informative to assess the potential human health risks of n-Ag in order to ensure that nano technology-based consumer products are deployed in a safe and sustainable way. Even though toxicity studies clearly show the potential hazard of n-Ag, there have been few attempts to integrate hazard and exposure assessments to evaluate risks. The underlying reason for this is the difficulty in characterizing exposure and the lack of toxicity studies essential for human health risk assessment (HHRA). Such data gaps introduce significant uncertainty into the risk assessment process. This study uses probabilistic methods to assess the relative uncertainty and potential risks of n-Ag exposure to infants. In this paper, we estimate the risks for infants potentially exposed to n-Ag through drinking juice or milk from sippy cups or licking baby blankets containing n-Ag. We explicitly evaluate uncertainty and variability contained in available dose-response and exposure data in order to make the risk characterization process transparent. Our results showed that individual margin of exposures for oral exposure to sippy cups and baby blankets containing n-Ag exhibited minimal risk. (C) 2016 Published by Elsevier Ltd.
机译：银纳米颗粒（n-Ag）由于其独特的抗菌特性而被广泛用于消费产品和许多医疗应用中。它们的使用引起人们对潜在的人类接触和健康影响的关注。因此，评估n-Ag对人类健康的潜在风险，以确保以安全和可持续的方式部署基于纳米技术的消费产品是有益的。即使毒性研究清楚地表明了n-Ag的潜在危害，也很少有人尝试将危害和暴露评估相结合来评估风险。造成这种情况的根本原因是难以确定暴露特征，并且缺乏对人类健康风险评估（HHRA）至关重要的毒性研究。这样的数据缺口为风险评估过程带来了很大的不确定性。这项研究使用概率方法评估婴儿接触n-Ag的相对不确定性和潜在风险。在本文中，我们估算了通过喝吸管杯或舔食含n-Ag的婴儿毛毯喝果汁或牛奶可能暴露于n-Ag的婴儿的风险。我们明确评估可用剂量反应和暴露数据中包含的不确定性和变异性，以使风险表征过程透明。我们的结果表明，口服含n-Ag的吸管杯和婴​​儿毛毯的个人接触风险最小。 （C）2016由Elsevier Ltd.出版

著录项

  • 来源
    《Environment international》 |2017年第2期|199-207|共9页
  • 作者

    Pang Chengfang; Hristozov Danail; Zabeo Alex; Pizzol Lisa; Tsang Michael P.; Sayre Phil; Marcomini Antonio;

  • 作者单位

    Ca Foscari Univ Venice, Dept Environm Sci Informat & Stat, Via Torino 155, I-30172 Venice, VE, Italy;

    Ca Foscari Univ Venice, Dept Environm Sci Informat & Stat, Via Torino 155, I-30172 Venice, VE, Italy|Green Decis Srl, Genoa, Italy;

    Ca Foscari Univ Venice, Dept Environm Sci Informat & Stat, Via Torino 155, I-30172 Venice, VE, Italy|Green Decis Srl, Genoa, Italy;

    Ca Foscari Univ Venice, Dept Environm Sci Informat & Stat, Via Torino 155, I-30172 Venice, VE, Italy|Green Decis Srl, Genoa, Italy;

    Univ Bordeaux, ISM, UMR 5255, F-33400 Talence, France|Univ Bordeaux, CNRS, ISM, UMR 5255, F-33400 Talence, France;

    US EPA, Washington, DC 20460 USA;

    Ca Foscari Univ Venice, Dept Environm Sci Informat & Stat, Via Torino 155, I-30172 Venice, VE, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Silver nanoparticles; Human health risk assessment; Engineered nanomaterials; Stochastic risk assessment;

    机译：银纳米颗粒;人类健康风险评估;工程纳米材料;随机风险评估;

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