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首页> 外文期刊>Environment international >Analysis of the sensitivity of in vitro bioassays for androgenic, progestagenic, glucocorticoid, thyroid and estrogenic activity: Suitability for drinking and environmental waters
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Analysis of the sensitivity of in vitro bioassays for androgenic, progestagenic, glucocorticoid, thyroid and estrogenic activity: Suitability for drinking and environmental waters

机译：体外生物测定对雄激素，孕激素，糖皮质激素，甲状腺和雌激素活性的敏感性分析：适用于饮用水和环境水

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摘要

The presence of endocrine disrupting chemicals in the aquatic environment poses a risk for ecosystem health. Consequently there is a need for sensitive tools, such as in vitro bioassays, to monitor endocrine activity in environmental waters. The aim of the current study was to assess whether current in vitro bioassays are suitable to detect endocrine activity in a range of water types. The reviewed assays included androgenic (n = 11), progestagenic (n = 6), glucocorticoid (n = 5), thyroid (n = 5) and estrogenic (n = 8) activity in both agonist and antagonist mode. Existing in vitro bioassay data were re-evaluated to determine assay sensitivity, with the calculated method detection limit compared with measured hormonal activity in treated wastewater, surface water and drinking water to quantify whether the studied assays were sufficiently sensitive for environmental samples. With typical sample enrichment, current in vitro bioassays are sufficiently sensitive to detect androgenic activity in treated wastewater and surface water, with anti-androgenic activity able to be detected in most environmental waters. Similarly, with sufficient enrichment, the studied mammalian assays are able to detect estrogenic activity even in drinking water samples. Fewer studies have focused on progestagenic and glucocorticoid activity, but some of the reviewed bioassays are suitable for detecting activity in treated wastewater and surface water. Even less is known about (anti)thyroid activity, but the available data suggests that the more sensitive reviewed bioassays are still unlikely to detect this type of activity in environmental waters. The findings of this review can help provide guidance on in vitro bioassay selection and required sample enrichment for optimised detection of endocrine activity in environmental waters. (C) 2016 Elsevier Ltd. All rights reserved.
机译：在水生环境中存在破坏内分泌的化学物质会对生态系统健康构成威胁。因此，需要灵敏的工具，例如体外生物测定法，以监测环境水中的内分泌活性。当前研究的目的是评估当前的体外生物测定是否适合检测多种水类型中的内分泌活性。回顾性分析包括激动剂和拮抗剂模式下的雄激素（n = 11），孕激素（n = 6），糖皮质激素（n = 5），甲状腺（n = 5）和雌激素（n = 8）活性。重新评估了现有的体外生物测定数据，以确定测定的灵敏度，将计算出的方法检出限与处理过的废水，地表水和饮用水中的激素活性进行比较，以量化所研究的测定对环境样品是否足够敏感。通过典型的样品富集，当前的体外生物测定对检测已处理废水和地表水中的雄激素活性足够敏感，并且在大多数环境水中都可以检测到抗雄激素活性。同样，经过足够的富集，所研究的哺乳动物分析甚至能够在饮用水样品中检测雌激素活性。很少有研究集中在孕激素和糖皮质激素的活性上，但是一些经过审查的生物测定方法适用于检测处理过的废水和地表水中的活性。关于（抗）甲状腺活性的了解甚少，但现有数据表明，更为敏感的综述性生物测定仍不太可能在环境水中检测到这种类型的活性。本综述的发现可为体外生物测定的选择和所需样品的富集提供指导，以优化检测环境水中的内分泌活性。 （C）2016 Elsevier Ltd.保留所有权利。

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