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首页> 外文期刊>Environment international >Selenium and exposure to fibrogenic mineral dust: A mini-review
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Selenium and exposure to fibrogenic mineral dust: A mini-review

机译：硒和纤维化矿物粉尘的暴露

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摘要

Individuals exposed to fibrogenic mineral dust may exhibit an impaired antioxidant system and produce high levels of reactive oxygen and nitrogen species through immune cells, contributing to the perturbation of immune cell function, inflammation, fibrosis and lung cancer. The lung diseases which are caused by inhalation of fibrogenic mineral dust, known as pneumoconioses, develop progressively and irreversibly over decades. At the moment there is no known cure. The Mace element selenium has potent antioxidant and anti-inflammatory properties mediated mainly through selenoproteins. Research has demonstrated that selenium has the ability to protect against cardiovascular diseases; to kill cancer cells in vitro and reduce cancer incidence; and to immunomodulate various cellular signaling pathways. For these reasons, selenium has been proposed as a promising therapeutic agent in oxidative stress associated pathology that in theory would be beneficial for the prevention or treatment of pneumoconioses such as silicosis, asbestosis, and coal worker's pneumoconiosis. However, studies regarding selenium and occupational lung diseases are rare. The purpose of this study is to conduct a mini-review regarding the relationship between selenium and exposure to fibrogenic mineral dust with emphasis on epidemiological studies. We carried out a systematic literature search of English published studies on selenium and exposure to fibrogenic mineral dust. We found four epidemiological studies. Reviewed studies show that selenium is lower in individuals exposed to fibrogenic mineral dust. However, three out of the four reviewed studies could not confirm cause-and-effect relationships between low selenium status and exposure to fibrogenic mineral dust. This mini-review underscores the need for large follow-up and mechanistic studies for selenium to further elucidate its therapeutic effects. (C) 2015 Elsevier Ltd. All rights reserved.
机译：暴露于纤维化矿物粉尘的个人可能会表现出抗氧化系统受损，并通过免疫细胞产生高水平的活性氧和氮，从而扰乱免疫细胞功能，炎症，纤维化和肺癌。吸入肺纤维化矿物粉尘引起的肺部疾病（称为尘肺）在数十年间逐步发展且不可逆转。目前尚无已知的治疗方法。锤头元素硒具​​有有效的抗氧化剂和抗炎特性，主要通过硒蛋白介导。研究表明硒具有预防心血管疾病的能力。在体外杀死癌细胞并降低癌症发生率；并免疫调节各种细胞信号通路。由于这些原因，已经提出硒作为氧化应激相关病理学中的有前途的治疗剂，其在理论上将对预防或治疗肺尘埃沉着症如硅肺病，石棉沉着症和煤工尘肺病有益。但是，关于硒和职业性肺病的研究很少。这项研究的目的是对硒与纤维化矿物粉尘接触与硒之间的关系进行一次简要回顾，重点是流行病学研究。我们对英文发表的有关硒和纤维化矿物粉尘暴露的研究进行了系统的文献检索。我们发现了四项流行病学研究。审查的研究表明，暴露于纤维化矿物粉尘的个体中硒含量较低。但是，四项综述性研究中有三项无法确定低硒状态与纤维化矿物粉尘暴露之间的因果关系。这份小型综述强调了对硒进行大规模随访和机理研究的必要性，以进一步阐明其治疗效果。 （C）2015 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environment international》 |2015年第4期|16-24|共9页
  • 作者

    Muzembo Basilua Andre; Deguchi Yoji; Ngatu Nlandu Roger; Eitoku Masamitsu; Hirota Ryoji; Suganuma Narufumi;

  • 作者单位

    Kochi Univ, Kochi Med Sch, Dept Environm Med, Div Social Med, Kochi 7838505, Japan|Japan Soc Promot Sci, Tokyo, Japan;

    Univ Fukui, Fac Med Sci, Sch Nursing, Fukui 910, Japan;

    Kochi Univ, Kochi Med Sch, Dept Environm Med, Div Social Med, Kochi 7838505, Japan|Kochi Univ, Disaster Grad Sch Hlth & Nursing Sci, Disaster Nursing Global Leader Program DNGL, Kochi 7838505, Japan;

    Kochi Univ, Kochi Med Sch, Dept Environm Med, Div Social Med, Kochi 7838505, Japan;

    Kochi Univ, Kochi Med Sch, Dept Environm Med, Div Social Med, Kochi 7838505, Japan;

    Kochi Univ, Kochi Med Sch, Dept Environm Med, Div Social Med, Kochi 7838505, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Selenium; Selenoproteins; Pneumoconiosis; Silicosis; Asbestosis; Coal miner's pneumoconiosis;

    机译：硒;硒蛋白;尘肺;矽肺;石棉沉着症;煤矿工人尘肺;

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