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Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

机译：巴基斯坦人口人类精浆中的有毒金属特征及其在男性不育中的潜在作用

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摘要

Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p < 0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r = -0.26, -0.29) and motility (r = -0.33, -0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan.
机译：这项研究的目的是提供有关人类精浆中微量金属发生率的第一手数据，并发现有毒金属水平与巴基斯坦人口精液质量之间可能的相关性。人体精液样本是从伊斯兰堡国家卫生研究所（巴基斯坦）接受不育评估的夫妇的男性伴侣中采集的。我们调查了75例精浆血浆样本，根据WHO指南将其进一步分为三类（正常精子症，少精子症和无精子症）。使用电感耦合等离子体质谱法（ICP-MS）同时测定人精浆中17种不同有毒金属的浓度。在17种痕量金属中，Cd和Ni在三个监测组之间显示出显着差异（p <0.05）。精浆中的镍和镉浓度分别与精子浓度（r = -0.26，-0.29）和运动力（r = -0.33，-0.37）呈负相关。这项研究表明，镍和镉的暴露主要与食用被污染的饮食项目有关，包括酥油（食用油），面粉和其他农产品。在一些精液样品中，Sn，V，Cu，Pb，Cr和Hg的浓度很高，这表明最近有人暴露于周围环境。在巴基斯坦的人类精液样本中，痕量金属的含量较低和/或与其他国家的人群相当。结果表明，有毒金属对巴基斯坦精液质量和男性不育的影响的第一个证据。

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  • 来源
    《Environmental Geochemistry and Health》 |2015年第3期|515-527|共13页
  • 作者

    Zafar Ambreen; Eqani Syed Ali Musstjab Akber Shah; Bostan Nazish; Cincinelli Alessandra; Tahir Faheem; Shah Syed Tahir Abbas; Hussain Alamdar; Alamdar Ambreen; Huang Qingyu; Peng Siyuan; Shen Heqing;

  • 作者单位

    COMSAT Inst Informat & Technol, Publ Hlth & Environm Div, Dept Biosci, Islamabad, Pakistan;

    COMSAT Inst Informat & Technol, Publ Hlth & Environm Div, Dept Biosci, Islamabad, Pakistan;

    COMSAT Inst Informat & Technol, Publ Hlth & Environm Div, Dept Biosci, Islamabad, Pakistan;

    Univ Florence, Dept Chem, I-50019 Florence, Italy;

    Natl Inst Hlth, Reprod Hlth Dept, Publ Hlth Labs Div, Islamabad, Pakistan;

    COMSAT Inst Informat & Technol, Publ Hlth & Environm Div, Dept Biosci, Islamabad, Pakistan;

    COMSAT Inst Informat & Technol, Publ Hlth & Environm Div, Dept Biosci, Islamabad, Pakistan;

    Chinese Acad Sci, Key Lab Urban Environm & Hlth, Inst Urban Environm, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Key Lab Urban Environm & Hlth, Inst Urban Environm, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Key Lab Urban Environm & Hlth, Inst Urban Environm, Xiamen 361021, Peoples R China;

    Chinese Acad Sci, Key Lab Urban Environm & Hlth, Inst Urban Environm, Xiamen 361021, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Human semen; Toxic metals; ICP-MS; Male infertility; Pakistan;

    机译：人精液;有毒金属;ICP-MS;男性不育;巴基斯坦;

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