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Theoretical environmental risk assessment of ten used Pharmaceuticals in Belo Horizonte, Brazil

机译：巴西贝洛·奥里州地区十次药品的理论环境风险评估

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摘要

An evaluation of the environmental risk assessment (ERA) proposed by European Medicines Agency (EMA) and its applicability in Brazil was performed on ten of Belo Horizonte's most pharmaceuticals by the Brazilian National Health Service (SUS). The predicted environmental concentrations (PECs) was proposed, with some refinements to a better representation of the city of study. All PECs obtained were compared only to measured environmental concentrations around the world, due to the lack available data in the city of study and in Brazil. During the performance of EMA's guideline, the risk quotient (RQ) of impact was established through the ratio of PECs and predicted no-effect concentrations (PNECs). The PECs obtained in more refined phases show the initial evaluation of EMA's guideline, possible subdimensions, and the potential risks. The RQ for all studied pharmaceuticals ranges from clonazepam (1.26) to losartan (5457.45). These results indicate potential risks to the aquatic life present in the streams that receive the wastewater treatment plant's effluent. This risk can be spread since the streams carry these contaminants to other water bodies that undergo to multiple cities of Brazil, and even after dilutions, it can still be potentially toxic to the biotic life. ERA shows that it can be a useful tool for a better understanding and modeling of pharmaceuticals fate in the environment, specifically in water bodies. In addition, the usage of this model shows to be a useful tool that determines which contaminant should follow a more thorough study since the detection and analysis of pharmaceuticals in environmental samples are costly and technically challenging.
机译：评估欧洲药物局（EMA）提出的环境风险评估（ERA）及其在巴西的适用性由巴西国家卫生服务（SUS）的大多数药品中的十名进行。提出了预测的环境浓度（PEC），有一些改进，以更好地代表学习。所获得的所有PEC都仅比较了世界各地的环境浓度，因为缺乏学习城市和巴西的可用数据。在EMA指南的表现期间，通过PEC的比率和预测的无效浓度（PNECS）的比例建立了影响的风险商（RQ）。在更精细的阶段获得的PEC显示了EMA的指南，可能的副职能和潜在风险的初步评估。所有学习的药品的RQ来自Clonazepam（1.26）到洛萨沙（5457.45）。这些结果表明潜在的水生寿命存在于接受废水处理厂的流出物的水生寿命。由于溪流将这些污染物携带到其他经历巴西城市的其他水体，即使在稀释后，这种风险也可以传播，甚至稀释，它仍然可能对生物生命潜在毒性。 ERA表明，它可以是一个有用的工具，以便更好地理解和建模在环境中，特别是在水体中的药物。此外，该模型的使用表明是一种有用的工具，以确定哪种污染物应该遵循更彻底的研究，因为环境样本中药物的检测和分析是昂贵的，技术上的具有挑战性。

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  • 来源
    《Environmental Monitoring and Assessment》 |2019年第5期|275.1-275.14|共14页
  • 作者

    Neves Arthur Couto; Gomes Mol Marcos Paulo;

  • 作者单位

    Fundacao Ezequiel Dias FUNED Diretoria Pesquisa & Desenvolvimento Rua Conde Pereira Carneiro 80 BR-30510010 Belo Horizonte MG Brazil|Ctr Fed Educ Tecnol Minas Gerais CEFET MG Belo Horizonte MG Brazil;

    Fundacao Ezequiel Dias FUNED Diretoria Pesquisa & Desenvolvimento Rua Conde Pereira Carneiro 80 BR-30510010 Belo Horizonte MG Brazil;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Drugs; Microcontaminants; Environment risk assessment;

    机译：药物;微免疫;环境风险评估;

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