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首页> 外文期刊>Environmental Pollution >Dendritic spine loss caused by AlCl_3 is associated with inhibition of the Rac 1/cofilin signaling pathway
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Dendritic spine loss caused by AlCl_3 is associated with inhibition of the Rac 1/cofilin signaling pathway

机译：AlCl_3引起的树突状脊柱丢失与Rac 1 / cofilin信号通路的抑制有关

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摘要

Aluminum (Al) has neurotoxicity that can result in cognitive dysfunction. Hippocampal dendritic spine loss is a pathological characteristic of cognitive dysfunction. Our previous study reported that Al exposure caused dendritic spine loss in the hippocampus, but the underlying mechanism remains unclear. In this study, rats were orally administered 50, 150 or 450 mg/kg of AlCl3 for 90 days. The dendritic spine density of the CA1 and DG regions was detected by Golgi-Cox staining. The F-actin/G-actin ratio, the expression of drebrin A and the components of the Rac 1/cofilin pathway were measured in the hippocampus. The results obtained showed that AlCl3 caused dendritic spine loss and decreased the F-actin/G-actin ratio. In addition, it was found that AlCl3 downregulated the expression of Rac 1, p-PAK, p-LIMK, p-cofilin and drebrin A and upregulated cofilin expression. Altogether, these results demonstrated that Al inactivated the Rac 1/cofilin pathway by inhibiting the phosphorylation of cofilin and the polymerization of F-actin, resulting in dendritic spine loss in the hippocampus. (C) 2018 Elsevier Ltd. All rights reserved.
机译：铝（Al）具有神经毒性，可导致认知功能障碍。海马树突状脊柱丢失是认知功能障碍的病理特征。我们先前的研究报道，铝的暴露会导致海马的树突状脊柱丢失，但其潜在机制仍不清楚。在这项研究中，大鼠口服给予50、150或450 mg / kg的AlCl3，持续90天。通过Golgi-Cox染色检测CA1和DG区域的树突棘密度。在海马中测量F-肌动蛋白/ G-肌动蛋白比，drebrinA的表达以及Rac 1 / cofilin途径的成分。获得的结果表明，AlCl3引起树突状脊柱丢失并降低F-肌动蛋白/ G-肌动蛋白比。此外，发现AlCl 3下调Rac 1，p-PAK，p-LIMK，p-cofilin和drebrin A的表达，并上调cofilin的表达。总而言之，这些结果表明Al通过抑制cofilin的磷酸化和F-actin的聚合而使Rac 1 / cofilin途径失活，从而导致海马体的树突状脊柱丢失。 （C）2018 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental Pollution》 |2018年第ptab期|1689-1695|共7页
  • 作者

    Yang Xu; Cao Zheng; Zhang Jian; Shao Bing; Song Miao; Han Yanfei; Li Yanfei;

  • 作者单位

    Northeast Agr Univ, Prov Educ Dept Heilongjiang Common Anim Dis Preve, Key Lab, Harbin 150030, Heilongjiang, Peoples R China;

    Northeast Agr Univ, Prov Educ Dept Heilongjiang Common Anim Dis Preve, Key Lab, Harbin 150030, Heilongjiang, Peoples R China;

    Northeast Agr Univ, Prov Educ Dept Heilongjiang Common Anim Dis Preve, Key Lab, Harbin 150030, Heilongjiang, Peoples R China;

    Northeast Agr Univ, Prov Educ Dept Heilongjiang Common Anim Dis Preve, Key Lab, Harbin 150030, Heilongjiang, Peoples R China;

    Northeast Agr Univ, Prov Educ Dept Heilongjiang Common Anim Dis Preve, Key Lab, Harbin 150030, Heilongjiang, Peoples R China;

    Northeast Agr Univ, Prov Educ Dept Heilongjiang Common Anim Dis Preve, Key Lab, Harbin 150030, Heilongjiang, Peoples R China;

    Northeast Agr Univ, Prov Educ Dept Heilongjiang Common Anim Dis Preve, Key Lab, Harbin 150030, Heilongjiang, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Aluminum; Dendritic spines; F-actin; Hippocampus; Rac 1/cofilin pathway; Drebrin A;

    机译：铝;树突棘;F-肌动蛋白;海马;Rac 1 / cofilin途径;Drebrin A;

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