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Air pollution and telomere length in adults: A systematic review and meta-analysis of observational studies

机译：成人的空气污染和端粒长度：观察性研究的系统评价和荟萃分析

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摘要

Telomere length (TL) has been suggested to be a surrogate for cellular ageing, and a record of cumulative inflammation and oxidative stress over life. An emerging body of evidence has associated exposure to air pollution to changes in TL. To date there is no available systematic review of literature on this association. We aimed to systematically review and conduct meta-analysis of published studies on the relationship between air pollution and TL in adults. Electronic databases were systematically searched for available English language studies on the association between air pollution and TL published up to 1 July 2018. Meta-analyses were conducted following MOOSE guidelines. The heterogeneity in the reported associations was assessed using Cochran's Q test and quantified as I-2 index. Publication bias was assessed using Egger's regression. Our search identified 19 eligible studies including 11 retrospective and eight prospective studies of which, four had excellent quality, ten had good quality and five had fair quality. Meta analysis result of two studies on long-term exposure to PM2.5 showed an inverse association between these exposures and it (for 5 mu g/m(3) PM2.5-0.03 95% CI; -0.05, -0.01). Meta-analysis of short-term exposure to PM2.5 with three studies and Polychlorinated Biphenyls (PCBs) with two studies revealed a direct association between these exposures and TL, (0.03 95% CI; 0.02, 0.04 and 0.10 95% CI; 0.06, 0.15 respectively). No statistically significant relationship between exposure to PM10 and polycyclic aromatic hydrocarbons (PAHs) exposure and it were observed. We observed suggestive evidence for associations between air pollution and TL with potentially different direction of associations for short- and long-term exposures. (C) 2018 Published by Elsevier Ltd.
机译：端粒长度（TL）被认为是细胞衰老的替代物，并且是终生累积炎症和氧化应激的记录。越来越多的证据表明空气污染与TL变化有关。迄今为止，尚无有关该关联的文献的系统综述。我们旨在系统地审查和进行关于成人空气污染与TL之间关系的已发表研究的荟萃分析。系统搜索电子数据库，以获取有关截至2018年7月1日发布的有关空气污染与TL之间关系的可用英语语言研究。按照MOOSE指南进行荟萃分析。使用Cochran's Q检验评估报告的关联中的异质性，并量化为I-2指数。使用Egger回归评估出版偏倚。我们的搜索确定了19项合格研究，包括11项回顾性研究和8项前瞻性研究，其中4项质量优异，10项质量良好，5项质量中等。两项关于长期暴露于PM2.5的研究的荟萃分析结果显示，这些暴露与PM2.5呈负相关（对于5μg / m（3）PM2.5-0.03 95％CI； -0.05，-0.01）。对三项研究的PM2.5短期暴露和两项研究的多氯联苯（PCB）进行的荟萃分析显示，这些暴露与TL有直接关联，（0.03 95％CI； 0.02、0.04和0.10 95％CI； 0.06 ，分别为0.15）。在PM10暴露与多环芳烃（PAHs）暴露之间没有统计学上的显着关系，并且可以观察到。我们观察到暗示性证据表明空气污染与TL之间存在关联，短期和长期暴露的关联方向可能不同。 （C）2018由Elsevier Ltd.发布

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  • 来源
    《Environmental Pollution》 |2019年第1期|636-647|共12页
  • 作者

    Miri Mohammad; Nazarzadeh Milad; Alahabadi Ahmad; Ehrampoush Mohammad Hassan; Rad Abolfazi; Lotfi Mohammad Hassan; Sheikhha Mohammad Hassan; Sakhvidi Mohammad Javad Zare; Nawrot Tim S.; Dadvand Payam;

  • 作者单位

    Sabzevar Univ Med Sci, Cellular & Mol Res Ctr, Sabzevar, Iran;

    Torbat Heydariyeh Univ Med Sci, Collaborat Ctr Meta Anal Res ccMETA, Torbat Heydariyeh, Iran;

    Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium;

    ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain;

    Shahid Sadoughi Univ Med Sci, Yazd Reprod Sci Inst, Res & Clin Ctr Infertil, Yazd, Iran;

    Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Yazd, Iran;

    Pompeu Fabra Univ, Barcelona, Catalonia, Spain;

    Univ Oxford, George Inst Global Hlth, Oxford, England;

    Ciber Epidemiol & Publ Hlth CIBERESP, Madrid, Spain;

    Sabzevar Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth, Cellular & Mol Res Ctr, Sabzevar, Iran;

    Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Occupat Hlth, Occupat Hlth Res Ctr, Yazd, Iran;

    Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium;

    Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth, Environm Sci & Technol Res Ctr, Yazd, Iran;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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