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首页> 外文期刊>Environmental Pollution >Mitigative effects of natural and model dissolved organic matter with different functionalities on the toxicity of methylmercury in embryonic zebrafish
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Mitigative effects of natural and model dissolved organic matter with different functionalities on the toxicity of methylmercury in embryonic zebrafish

机译：不同功能的天然和模型溶解有机物对斑马鱼胚胎中甲基汞毒性的缓解作用

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摘要

Dissolved organic matter (DOM) occurs ubiquitously in aquatic environments and plays an intrinsic role in altering the chemical speciation and toxicity of methylmercury (MeHg). However, interactions between MeHg and natural DOM remain poorly understood, especially at the functional group level. We report here the mitigative effects of three natural organic matter (NOM) and five model-DOM under different concentrations (0, 1, 3, 10, 30 and 100 mg-C/L) on the toxicity of MeHg in embryonic zebrafish (<4 h post-fertilization, hpf). NOM are those from the Mississippi River, Yukon River, and Suwannee River, while model-DOM include those containing thiosalicylic acid, L-glutathione, dextran, alginic acid, and humic acid. We selected a MeHg concentration (100 n-mol/L) that reduces the survival rate of embryos at 24 hpf by 18% and increases malformations at 72 and 96 hpf. In the presence of DOM, however, the malformation rates induced by MeHg can be mitigated to a different extent depending on DOM concentrations, specific functional groups, and/or specific components. Model DOM with aromatic thiols was the most effective at mitigating the effects of MeHg, followed by L-glutathione, carbohydrates, and humic acid. NOM also mitigated the toxicity of MeHg dependent on their composition and/or effective DOM components as characterized by fluorescence excitation-emission matrix techniques. Specifically, humic-like DOM components are more effective in reducing the MeHg toxicity in the embryonic zebrafish compared to protein-like components. Further studies are needed to elucidate the interactions between DOM and MeHg and the mitigative mechanisms at the molecular level. (C) 2019 Elsevier Ltd. All rights reserved.
机译：溶解有机物（DOM）普遍存在于水生环境中，并且在改变甲基汞（MeHg）的化学形态和毒性方面起着固有的作用。但是，MeHg和天然DOM之间的相互作用仍然知之甚少，尤其是在功能组一级。我们在这里报告了三种天然有机物（NOM）和五种模型DOM在不同浓度（0、1、3、10、30和100 mg-C / L）下对MeHg在胚胎斑马鱼中的毒性的缓解作用（<受精后4小时，hpf）。 NOM是来自密西西比河，育空河和苏万尼河的那些，而DOM模型包括含有硫代水杨酸，L-谷胱甘肽，右旋糖酐，藻酸和腐殖酸的那些。我们选择的MeHg浓度（100 n-mol / L）使24 hpf下的胚胎存活率降低18％，并增加72和96 hpf下的畸形。但是，在存在DOM的情况下，取决于DOM浓度，特定的官能团和/或特定的成分，MeHg诱导的畸形率可以不同程度地减轻。带有芳香族硫醇的DOM模型在减轻MeHg的影响方面最有效，其次是L-谷胱甘肽，碳水化合物和腐殖酸。 NOM还可以减轻MeHg的毒性，这取决于其组成和/或有效DOM成分，如荧光激发-发射矩阵技术所表征。具体地说，与类蛋白质成分相比，类腐殖质DOM成分在降低斑马鱼胚胎中的MeHg毒性方面更为有效。需要进一步的研究来阐明DOM和MeHg之间的相互作用以及分子水平上的缓解机制。 （C）2019 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental Pollution》 |2019年第1期|616-626|共11页
  • 作者

    Li Dan; Xie Lingtian; Carvan Michael J. III; Guo Laodong;

  • 作者单位

    Univ Wisconsin Sch Freshwater Sci 600 E Greenfield Ave Milwaukee WI 53204 USA|Chinese Acad Sci Inst Appl Ecol Key Lab Pollut Ecol & Environm Engn Shenyang 110016 Peoples R China|Univ Chinese Acad Sci Beijing 100049 Peoples R China;

    South China Normal Univ Guangdong Prov Key Lab Chem Pollut & Environm Saf SCNU Environm Res Inst Guangzhou 510006 Guangdong Peoples R China|South China Normal Univ MOE Key Lab Environm Theoret Chem Guangzhou 510006 Guangdong Peoples R China;

    Univ Wisconsin Sch Freshwater Sci 600 E Greenfield Ave Milwaukee WI 53204 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Methylmercury toxicity; Dissolved organic matter; Natural organic matter; Embryonic zebrafish; Mitigative effect;

    机译：甲基汞毒性;溶解的有机物;天然有机物;胚胎斑马鱼;缓解效果;

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