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首页> 外文期刊>Environmental Pollution >Unraveling the toxic effects of neonicotinoid insecticides on the thyroid endocrine system of lizards
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Unraveling the toxic effects of neonicotinoid insecticides on the thyroid endocrine system of lizards

机译：阐明新烟碱类杀虫剂对蜥蜴甲状腺内分泌系统的毒性作用

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摘要

The widespread use of neonicotinoids has resulted in large residues in the soil, which has a major impact on the lizards that inhabit the soil. Thyroid hormones play an important role in the growth and development of lizards. In this report, we assessed the disrupting effects of thyroid system on lizards after 28 days of continuous exposure to dinotefuran, thiamethoxam, and imidacloprid, respectively. Neonicotinoid insecticides could seriously affect the concentration of T4 in lizard plasma and the conversion of T4 to T3 in the thyroid gland. Specifically, exposure to dinotefuran affected the intake and utilization of iodine in the thyroid gland, resulting in insufficient thyroid function, which in turn lead to thyroid epithelial hyperplasia and follicular volume enlargement by negative feedback. Exposure to thiamethoxam could activate thyroid function, significantly increasing plasma T3 and T4 concentrations and promoting the binding of T3 and thyroid hormone receptors. lmidacloprid exposure could inhibit the secretion of thyroid hormones, leading to down-regulation of thyroid hormone receptors and related phase II metabolic enzyme genes. This study verified that the continuous exposure of neonicotinoids could affect the lizard thyroid endocrine system. The harm of neonicotinoids to reptiles deserved more attention. (C) 2019 Elsevier Ltd. All rights reserved.
机译：新烟碱的广泛使用已在土壤中产生大量残留物，这对居住在土壤中的蜥蜴有重大影响。甲状腺激素在蜥蜴的生长发育中起着重要作用。在本报告中，我们分别评估了连续28天分别暴露于二甲呋喃，噻虫嗪和吡虫啉后28天甲状腺系统对蜥蜴的破坏作用。新烟碱类杀虫剂可能会严重影响蜥蜴血浆中T4的浓度以及甲状腺中T4向T3的转化。具体而言，接触二甲呋喃会影响甲状腺中碘的摄入和利用，导致甲状腺功能不足，进而导致甲状腺上皮增生和负反馈导致卵泡体积增大。接触噻虫嗪可以激活甲状腺功能，显着增加血浆T3和T4浓度并促进T3和甲状腺激素受体的结合。吡虫啉暴露可能抑制甲状腺激素的分泌，导致甲状腺激素受体和相关的II期代谢酶基因下调。这项研究证实，新烟碱类药物的持续暴露可能会影响蜥蜴的甲状腺内分泌系统。新烟碱对爬行动物的危害值得更多关注。 （C）2019 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental Pollution》 |2020年第3期|113731.1-113731.7|共7页
  • 作者

  • 作者单位

    Chinese Acad Sci Res Ctr Ecoenvironm Sci 18 Shuangqing Rd Beijing 100085 Peoples R China;

    Linyi Univ Coll Resource & Environm Shandong Prov Key Lab Water & Soil Conservat & En Linyi 276005 Shandong Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Neonicotinoids; Lizards; Thyroid; Disrupting effects;

    机译：新烟碱类;蜥蜴;甲状腺;破坏效果;

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