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首页> 外文期刊>Environmental pollution >Effects of lead, cadmium, arsenic, and mercury co-exposure on children's intelligence quotient in an industrialized area of southern China
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Effects of lead, cadmium, arsenic, and mercury co-exposure on children's intelligence quotient in an industrialized area of southern China

机译：铅，镉，砷和汞的共同暴露对华南工业区儿童智力商的影响

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摘要

Exposure to metal(loid)s can lead to adverse effects on nervous system in children. However, little is known about the possible interaction effects of simultaneous exposure to multiple metal(loid)s on children's intelligence. In addition, relationship between blood lead concentrations (100 mu g/L) and the intelligence of children over 5 years needs further epidemiological evidence. We recruited 530 children aged 9-11 years, including 266 living in a town near an industrialized area and 264 from another town in the same city in South China as a reference. The levels of lead (Pb), cadmium (Cd), arsenic (As) and mercury (Hg) in blood (BPb, BCd, BAs, BHg) and urine (UPb, UCd, UAs, UHg) were assessed, as well as children's intelligence quotient (IQ). A significant decrease in IQ scores was identified in children from the industrialized town (p .05), who had statistically higher geometric mean concentrations of BPb, BCd, UPb, UCd and UHg (65.89, 1.93, 4.04, 1.43 and 0.37 mu g/L, respectively) compared with children from the reference town (37.21, 1.07, 2.14,1.02 and 0.30 mu g/L, respectively, p .05). After adjusting confounders, only BPb had a significant negative association with IQ (B = -0.10, 95% confidence interval: -0.15 to -0.05, p .001), which indicated that IQ decreased 0.10 points when BPb increased 1 mu g/L. Significant negative interactions between BAs and BHg, positive interaction between UPb and UCd on IQ were observed (p .10), and BPb 100 mu g/L still negatively affected IQ (p .05). Our findings suggest that although only BPb causes a decline in children's IQ when simultaneously exposed to these four metal(loid)s at relatively low levels, interactions between metal(loid)s on children's IQ should be paid special attention, and the reference standard in China of 100 mu g/L BPb for children above 5 years old should be revised. (C) 2017 Elsevier Ltd. All rights reserved.
机译：暴露于金属（胶体）会导致儿童神经系统受到不良影响。然而，关于同时暴露于多种金属（金属）对儿童智力的可能相互作用影响知之甚少。此外，血铅浓度（<100微克/升）与5岁以上儿童的智力之间的关系还需要进一步的流行病学证据。我们招募了530名9-11岁的儿童，其中包括266名居住在工业化地区附近的城镇中的儿童和264名居住在华南同一城市另一城镇的儿童作为参考。评估了血液（BPb，BCd，BAs，BHg）和尿液（UPb，UCd，UAs，UHg）中铅（Pb），镉（Cd），砷（As）和汞（Hg）的水平，以及儿童的智商（IQ）。在工业化城镇的儿童中，智商得分显着下降（p <.05），他们的BPb，BCd，UPb，UCd和UHg的几何平均浓度在统计学上较高（65.89、1.93、4.04、1.43和0.37μg / L）与参考镇的儿童（分别为37.21、1.07、2.14、1.02和0.30μg / L）进行比较（p <.05）。调整混杂因素后，只有BPb与IQ呈显着负相关（B = -0.10，95％置信区间：-0.15至-0.05，p <.001），这表明当BPb增加1μg/ g时IQ降低0.10点。 L.观察到BA和BHg之间存在显着的负相互作用，UPb与UCd之间在IQ方面存在正相互作用（p <.10），而BPb <100μg / L仍对IQ有负面影响（p <.05）。我们的研究结果表明，虽然只有BPb在同时以相对较低的水平同时暴露于这四种金属（金属）时会导致儿童智商下降，但应特别注意金属（金属）之间对儿童智商的相互作用，并参考应修订针对5岁以上儿童的100μg / L BPb的规定。 （C）2017 Elsevier Ltd.保留所有权利。

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  • 来源
    《Environmental pollution》 |2018年第4期|47-54|共8页
  • 作者

    Pan Shangxia; Lin Lifeng; Zeng Fan; Zhang Jianpeng; Dong Guanghui; Yang Boyi; Jing You; Chen Shejun; Zhang Gan; Yu Zhiqiang; Sheng Guoying; Ma Huimin;

  • 作者单位

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Guangdong, Peoples R China;

    Ctr Dis Control & Prevent Qujiang Dist, Shaoguan 512100, Peoples R China;

    Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Publ Hlth, Dept Prevent Med, Guangzhou 510080, Guangdong, Peoples R China;

    Sun Yat Sen Univ, Sch Publ Hlth, Dept Prevent Med, Guangzhou 510080, Guangdong, Peoples R China;

    Jinan Univ, Guangzhou Key Lab Environm Exposure & Hlth, Sch Environm, Guangzhou 510632, Guangdong, Peoples R China;

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

    Chinese Acad Sci, State Key Lab Organ Geochem, Guangzhou Inst Geochem, Guangzhou 510640, Guangdong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Lead; Cadmium; Arsenic; Mercury; Intelligence quotient scores;

    机译：铅;镉;砷;汞;智能商分数;

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